Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
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DOI: 10.1021/acs.jmedchem.8b01529
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified… read more here.
Keywords: endonuclease; inhibition ape1; apurinic apyrimidinic; macrocyclic inhibitors ... See more keywords