Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Biotechnology"
DOI: 10.1038/s41587-024-02346-5
Abstract: Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of high-affinity antibodies with therapeutic potential.… read more here.
Keywords: antibody; antibody secreting; discovery monoclonal; secreting cells ... See more keywords
Discovery of a monoclonal, high‐affinity CD8+ T‐cell clone following natural hepatitis C virus infection
Sign Up to like & getrecommendations! Published in 2024 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12791
Abstract: CD8+ T cells recognizing their cognate antigen are typically recruited as a polyclonal population consisting of multiple clonotypes with varying T‐cell receptor (TCR) affinity to the target peptide–major histocompatibility complex (pMHC) complex. Advances in single‐cell… read more here.
Keywords: discovery monoclonal; affinity; cell; infection ... See more keywords