Targeted Discovery of a Natural ortho-Quinone Methide Precursor and Green Generation of Its Oligomers.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c00035
Abstract: ortho-Quinone methides (o-QMs) are a class of highly reactive intermediates that serve as important nonisolable building blocks (NBBs) in organic synthesis and small-molecule library construction. Because of their instability and nonisolability, most reported o-QMs are… read more here.
Keywords: generation; precursor; ortho quinone; discovery natural ... See more keywords
Discovery of natural scaffolds as HER2 inhibitors for breast cancer: virtual screening, molecular dynamics, and biological characterization with selectivity profiling
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DOI: 10.1038/s41598-025-11177-6
Abstract: Nature offers potential therapeutic candidates for breast cancer (BC), and targeting HER2 signaling presents a promising approach, leveraging the successful history of anticancer drug discovery. Using a structure-based virtual screening workflow, a comprehensive library of… read more here.
Keywords: cancer; breast cancer; virtual screening; discovery natural ... See more keywords
Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination
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DOI: 10.1111/bph.17320
Abstract: NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product… read more here.
Keywords: derivative triptolidiol; natural product; discovery natural; nlrp3 ... See more keywords
Editorial: Drug discovery from natural sources: Animal venoms, plants, bacteria and fungi
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.998676
Abstract: Through several thousand million years of adaptive evolution, venomous animal species, toxic plants, and microorganisms have developed a large group of high-affinity and stable natural-based biomolecules, which have now been isolated and identified. Some of… read more here.
Keywords: drug discovery; natural based; editorial drug; discovery natural ... See more keywords
Editorial: Treatment of Alzheimer’s disease-discovery of natural products based on neurite outgrowth and neuroprotection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1079783
Abstract: Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Institute of Nutrition and Marine Drugs, Guangdong Ocean University, Zhanjiang, China, Key Laboratory of Digital Quality Evaluation of Chinese… read more here.
Keywords: disease discovery; treatment alzheimer; natural products; alzheimer disease ... See more keywords
Lead/Drug Discovery from Natural Resources
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DOI: 10.3390/molecules27238280
Abstract: Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for… read more here.
Keywords: drug discovery; natural resources; lead drug; discovery natural ... See more keywords
Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches
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DOI: 10.3390/nu13010254
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease conceptualized as a clinical-biological neurodegenerative construct where amyloid-beta pathophysiology is supposed to play a role. The loss of cognitive functions is mostly characterized by the rapid hydrolysis of… read more here.
Keywords: natural inhibitors; cholinesterases hydrangea; hydrangea vitro; vitro silico ... See more keywords
Discovery of Natural Phosphodiesterase 5 Inhibitors from Dalbergia cochinchinensis Pierre Leaves Using LC-QTOF-MS2
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DOI: 10.3390/plants14111652
Abstract: The imbalance of phosphodiesterase 5 (PDE5) enzyme in the male body, or excessive PDE5 enzyme levels, can occur due to factors such as aging, diseases (e.g., cardiovascular disease, diabetes, depressive disorder), and physical behaviors (e.g.,… read more here.
Keywords: cochinchinensis; qtof ms2; phosphodiesterase; discovery natural ... See more keywords