Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21591
Abstract: A series of aminobenzoquinones, denoted as PQ analogs (PQ1‐13), were synthesized by employing a green methodology approach using water as solvent developed by Tandon et al. Subsequently, in vitro antimicrobial potential of all PQ analogs… read more here.
Keywords: pq9 pq11; evaluation; new family; family heterocyclic ... See more keywords
Discovery of new code interference phenomenon in GPS observables
Sign Up to like & getrecommendations! Published in 2019 at "GPS Solutions"
DOI: 10.1007/s10291-019-0858-7
Abstract: The Global Positioning System (GPS) provides satellite-based navigation signals, which are employed in many fields, including agriculture, transportation, aviation, and military/personal navigation. In an effort to minimize interference among GPS satellites and to enable GPS… read more here.
Keywords: code interference; interference; gps; new code ... See more keywords
Bioinformatics tools for the discovery of new lipopeptides with biocontrol applications
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Plant Pathology"
DOI: 10.1007/s10658-018-1544-2
Abstract: As conventional or chemical pesticides have negative impact on environment and health of both farmer and consumers, it becomes relevant to develop alternative solutions to limit their use. In this context, innovative strategies to accelerate… read more here.
Keywords: new lipopeptides; bioinformatics tools; tools discovery; biocontrol applications ... See more keywords
Discovery of a new crystal structure of LiBeF3 and its thermodynamic and optical properties
Sign Up to like & getrecommendations! Published in 2019 at "Computational Materials Science"
DOI: 10.1016/j.commatsci.2019.109077
Abstract: Abstract This article reports a newly discovered crystal structure of LiBeF3 from approximately 700 candidate structures by means of high-throughput DFT (Density Functional Theory) screening. The lowest-energy structure is monoclinic with the P2/c symmetry and… read more here.
Keywords: libef3 thermodynamic; structure; crystal structure; structure libef3 ... See more keywords
Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.053
Abstract: Persistent activated STAT3 has a striking correlation with cancer development and inhibition of STAT3 signaling pathway is a novel therapeutic way for human cancers. Among STAT family, STAT1 and STAT3 play opposite roles in tumorigenesis.… read more here.
Keywords: discovery new; new benzensulfonamide; derivatives tripedal; stat3 ... See more keywords
Discovery of new salivary gland – A substantial histological analysis
Sign Up to like & getrecommendations! Published in 2021 at "Radiotherapy and Oncology"
DOI: 10.1016/j.radonc.2021.06.004
Abstract: Regardless of the COVID-19 pandemic in 2020, discovering a new salivary gland turned into all the rage among the medical fraternity. The significance of the disclosure has been correlated with its clinical relevance in radiotherapy… read more here.
Keywords: new salivary; salivary gland; substantial histological; gland substantial ... See more keywords
Trifluoromethylpyridine: An Important Active Fragment for the Discovery of New Pesticides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08383
Abstract: Trifluoromethylpyridine (TFMP) is a biologically active fragment formed by connecting trifluoromethyl and pyridine ring. As a result of its unique physical and chemical properties and outstanding biological activity, a variety of pesticide compounds with the… read more here.
Keywords: fragment; important active; trifluoromethylpyridine important; active fragment ... See more keywords
Spiro Derivatives in the Discovery of New Pesticides: A Research Review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02301
Abstract: Spiro compounds are biologically active organic compounds with unique structures, found in a wide variety of natural products and drugs. They do not readily lead to drug resistance due to their unique mechanisms of action… read more here.
Keywords: new pesticides; spiro compounds; derivatives discovery; discovery new ... See more keywords
Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00496
Abstract: Alzheimer's disorder is one of the most common world-wide health problems and its prevalence continues to increase thereby straining the healthcare budgets of both developed and developing countries. We report herein a new donepezil-like natural… read more here.
Keywords: new donepezil; inhibitor; donepezil like; like acetylcholinesterase ... See more keywords
Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00249
Abstract: In recent years, the selective inhibition of FKBP51 has emerged as a possible treatment for chronic pain, obesity-induced diabetes, or depression. All currently known advanced FKBP51-selective inhibitors, including the widely used SAFit2, contain a cyclohexyl… read more here.
Keywords: discovery new; based discovery; selectivity; new selectivity ... See more keywords
Computational discovery of new 2D materials using deep learning generative models
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c01044
Abstract: Two-dimensional (2D) materials have emerged as promising functional materials with many applications such as semiconductors and photovoltaics because of their unique optoelectronic properties. Although several thousand 2D materials have been screened in existing materials databases,… read more here.
Keywords: learning; computational discovery; new materials; deep learning ... See more keywords