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   Articles with "discovery non" as a keyword



Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors

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recommendations! Published in 2024 at "ChemMedChem"

DOI: 10.1002/cmdc.202300613

Abstract: The Werner Syndrome RecQ helicase (WRN) is a synthetic lethal target of interest for the treatment of cancers with microsatellite instability (MSI). Different hit finding approaches were initially tested. The identification of WRN inhibitors proved… read more here.

Keywords: helicase inhibitors; helicase; discovery non; wrn helicase ... See more keywords
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Discovery of non-peptide GLP-1r natural agonists for enhancing coronary safety in type 2 diabetes patients

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recommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2023.2298734

Abstract: Abstract This study explores the computational discovery of non-peptide agonists targeting the Glucagon-Like Peptide-1 Receptor (GLP-1R) to enhance the safety of major coronary outcomes in individuals affected by Type 2 Diabetes. The objective is to… read more here.

Keywords: discovery non; type diabetes; non peptide; coronary safety ... See more keywords

‘Discovery’ of non-traditional agricultural exports in Latin America: diverging pathways through learning and innovation

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recommendations! Published in 2017 at "Innovation and Development"

DOI: 10.1080/2157930x.2017.1355771

Abstract: ABSTRACT Diversification of exports plays a critical role in economic growth and development, especially for countries endowed with natural resources. Successful cases often take advantage of a so-called natural resource knowledge idiosyncrasy, a unique combination… read more here.

Keywords: discovery non; non traditional; innovation; traditional agricultural ... See more keywords

Discovery of the non-cosmopolitan lineages in Candidatus Thermoprofundales.

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recommendations! Published in 2022 at "Environmental microbiology"

DOI: 10.1111/1462-2920.15965

Abstract: The recently proposed order Candidatus Thermoprofundales, currently containing only one family-level lineage Marine Benthic Group-D (MBG-D), is distributed in global subsurface ecosystems and ecologically important, but its diversity, evolution and metabolism remain largely unknown. Here… read more here.

Keywords: lineages candidatus; non cosmopolitan; oil reservoirs; discovery non ... See more keywords

Discovery of Non-Peptidic Compounds against Chagas Disease Applying Pharmacophore Guided Molecular Modelling Approaches

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recommendations! Published in 2018 at "Molecules"

DOI: 10.3390/molecules23123054

Abstract: Chagas disease is one of the primary causes of heart diseases accounting to 50,000 lives annually and is listed as the neglected tropical disease. Because the currently available therapies have greater toxic effects with higher… read more here.

Keywords: discovery non; non peptidic; chagas disease; disease ... See more keywords