Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2931
Abstract: Ameloblastoma is a rare odontogenic benign tumor accounting for less than 1% of head and neck tumors. Advanced next generation sequencing (NGS) analyses identified high frequency of BRAF V600E and SMO L412F mutations in ameloblastoma.… read more here.
Keywords: medicine; kras responsive; ameloblastoma cells; ameloblastoma ... See more keywords
Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202000874
Abstract: Human purine nucleoside phosphorylase (HsPNP) belongs to the purine salvage pathway of nucleic acids. Genetic deficiency of this enzyme triggers apoptosis of activated T‐cells due to the accumulation of deoxyguanosine triphosphate (dGTP). Therefore, potential chemotherapeutic… read more here.
Keywords: purine nucleoside; human purine; discovery novel; interaction ... See more keywords
Discovery of novel halogenated 8‐hydroxyquinoline‐based anti‐MRSA agents: In vitro and QSAR studies
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21611
Abstract: Methicillin‐resistant Staphylococcus aureus (MRSA) infection has been considered to be one of global health problems due to limited classes of effective antimicrobial drugs. Herein, 8‐hydroxyquinoline (8HQ) and its derivatives (1‐7) were investigated for their anti‐MRSA… read more here.
Keywords: anti mrsa; novel halogenated; hydroxyquinoline; discovery novel ... See more keywords
Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin‐1 binding of small molecules
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21641
Abstract: Neuropilin‐1 (NRP1) is emerging as an important molecule in immune signaling where it has been shown to modulate the actions of TGF‐β1 in macrophages and regulatory T cells. The development of cost‐effective and reliable assays… read more here.
Keywords: novel fluorescent; small molecules; fluorescent chemical; probe suitable ... See more keywords
Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning
Sign Up to like & getrecommendations! Published in 2019 at "ChemistryOpen"
DOI: 10.1002/open.201800270
Abstract: Abstract Invited for this month's cover picture is the group of Prof. Dr. Gisbert Schneider from the Swiss Federal Institute of Technology (ETH) Zurich (Switzerland). The cover picture illustrates the application of machine‐learning methods to expand… read more here.
Keywords: machine; machine learning; farnesoid receptor; discovery novel ... See more keywords
Discovery of novel (N-aryl-4-methylpiperidinyl)pyrazoles: A new class of potent lepidopteran insecticides.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7349
Abstract: BACKGROUND Insects of the order Lepidoptera are among the most destructive global pests causing billions of dollars in damage annually. A new class of N-arylpyrazole-4-methylpiperidines with potent activity on lepidopteran species has been discovered. RESULTS… read more here.
Keywords: discovery novel; novel aryl; class; new class ... See more keywords
Discovery of novel inhibitors of human galactokinase by virtual screening
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-019-00190-3
Abstract: Classic Galactosemia is a potentially lethal autosomal recessive metabolic disorder caused by deficient galactose-1-phosphate uridyltransferase (GALT) that results in the buildup of galactose-1-phosphate (gal-1-p) in cells. Galactokinase (GALK1) is the enzyme responsible for converting galactose… read more here.
Keywords: virtual screening; inhibitors human; discovery novel; novel inhibitors ... See more keywords
Target Discovery of Novel α-l-Rhamnosidases from Human Fecal Metagenome and Application for Biotransformation of Natural Flavonoid Glycosides
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-019-03063-5
Abstract: As a green and powerful tool, biocatalysis has emerged as a perfect alternative to traditional chemistry. The bottleneck during process development is discovery of novel enzymes with desired properties and independent intellectual property. Herein, we… read more here.
Keywords: rhamnosidases human; novel rhamnosidases; discovery; three novel ... See more keywords
Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of microbiology"
DOI: 10.1007/s12275-021-1292-4
Abstract: C-Glycosides are an important type of natural product with significant bioactivities, and the C-glycosidic bonds of C-glycosides can be cleaved by several intestinal bacteria, as exemplified by the human faeces-derived puerarin-degrading bacterium Dorea strain PUE.… read more here.
Keywords: discovery novel; similarity network; glycoside hydrolases; sequence similarity ... See more keywords
In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking
Sign Up to like & getrecommendations! Published in 2017 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-017-0126-x
Abstract: Coagulation Factor Xa (FXa) is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways. The inhibition of FXa is an effective approach against thrombotic diseases. In the present study, a… read more here.
Keywords: fxa inhibitors; fxa; discovery novel; silico discovery ... See more keywords
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.07.018
Abstract: Abstract Bromodomain containing protein 4 (BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases, including cancer, cardiac remodeling… read more here.
Keywords: phenylquinazoline; discovery novel; cardiac fibrosis; novel phenylquinazoline ... See more keywords