Discovery of PARP1-Sparing Inhibitors for Protein ADP-Ribosylation
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DOI: 10.1021/acsmedchemlett.4c00395
Abstract: Poly-ADP-ribose polymerases (PARPs) that catalyze cellular ADP-ribosylation play important roles in human health. PARP inhibitors have found success in the clinic for cancer treatment. However, isoform-specific inhibitors are needed for improved safety. Here, we report… read more here.
Keywords: sparing inhibitors; adp ribosylation; parp1 sparing; discovery parp1 ... See more keywords