Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02110
Abstract: Glucokinase (GK) is a key regulator of glucose homeostasis, and its small-molecule activators represent a promising opportunity for the treatment of type 2 diabetes. Several GK activators have been advanced into clinical trials and have… read more here.
Keywords: phosphonate; bms 820132; discovery partial; partial glucokinase ... See more keywords
Data-driven discovery of partial differential equation models with latent variables
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DOI: 10.1103/physreve.100.022219
Abstract: In spatially extended systems, it is common to find latent variables that are hard, or even impossible, to measure with acceptable precision but are crucially important for the proper description of the dynamics. This substantially… read more here.
Keywords: discovery partial; partial differential; driven discovery; equation ... See more keywords