Human defensin-inspired discovery of peptidomimetic antibiotics
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DOI: 10.1073/pnas.2117283119
Abstract: Significance We report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with… read more here.
Keywords: peptidomimetic antibiotics; inspired discovery; discovery peptidomimetic; defensin inspired ... See more keywords