Discovery of a Phosphodiesterase 7A Inhibitor of High Isozyme Selectivity Exhibiting In Vivo Anti-Osteoporotic Effects.
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DOI: 10.1021/acsmedchemlett.4c00570
Abstract: Phosphodiesterases (PDEs) have drawn attention due to their critical roles in physiological and pathological conditions. Many research groups have studied these hydrolytic enzymes to develop new drugs, including apremilast as a PDE4 inhibitor and sildenafil… read more here.
Keywords: isozyme; discovery phosphodiesterase; phosphodiesterase inhibitor; selectivity ... See more keywords