Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
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DOI: 10.1021/acsmedchemlett.1c00682
Abstract: Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human cancer progression as well as… read more here.
Keywords: phospholipase; phospholipase inhibitors; discovery phospholipase; pld ... See more keywords