An “All-In-One” Pharmacophoric Architecture for the Discovery of Potential Broad-Spectrum Anti-Flavivirus Drugs
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-017-2690-2
Abstract: A precipitous increase in the number of flaviviral infections has been noted over the last 5 years. Despite these outbreaks, treatment protocols for infected individuals remain ambiguous. Numerous studies have identified NITD008 as a potent flavivirus… read more here.
Keywords: discovery potential; spectrum; pharmacophoric architecture; one pharmacophoric ... See more keywords
Discovery of potential novel CRBN modulators by virtual screening and bioassay.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114355
Abstract: The incidence of malignant tumor with high mortality is increasing yearly. CRBN E3 ubiquitin ligase was proved to be an antitumor target. It was found that thalidomide and its analogs could bind to CRBN E3… read more here.
Keywords: modulators virtual; crbn; virtual screening; crbn modulators ... See more keywords
Discovery potential of Higgs boson pair production through final states at a 100 TeV collider
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Physics C"
DOI: 10.1088/1674-1137/41/2/023105
Abstract: We explore the discovery potential of Higgs pair production at a 100 TeV collider via full leptonic mode. The same mode can be explored at the LHC when Higgs pair production is enhanced by new… read more here.
Keywords: discovery potential; 100 tev; pair; potential higgs ... See more keywords
Sensitivity and discovery potential of the proposed nEXO experiment to neutrinoless double- β decay
Sign Up to like & getrecommendations! Published in 2018 at "Physical Review C"
DOI: 10.1103/physrevc.97.065503
Abstract: The next-generation Enriched Xenon Observatory (nEXO) is a proposed experiment to search for neutrinoless double-β (0νββ) decay in Xe136 with a target half-life sensitivity of approximately 1028 yr using 5×103 kg of isotopically enriched liquid-xenon… read more here.
Keywords: discovery potential; sensitivity; neutrinoless double; double decay ... See more keywords
Discovery potential of multiton xenon detectors in neutrino electromagnetic properties
Sign Up to like & getrecommendations! Published in 2019 at "Physical Review D"
DOI: 10.1103/physrevd.100.073001
Abstract: Next-generation xenon detectors with multiton-year exposure are powerful direct probes of dark matter candidates, in particular the favorite weakly interacting massive particles. Coupled with the features of low thresholds and backgrounds, they are also excellent… read more here.
Keywords: detectors neutrino; multiton xenon; xenon detectors; potential multiton ... See more keywords
Fragment-based Discovery of Potential Anticancer Lead: Computational and in Vitro Studies.
Sign Up to like & getrecommendations! Published in 2020 at "Current computer-aided drug design"
DOI: 10.2174/1573409916666200620195025
Abstract: BACKGROUND The human epidermal growth factor receptor 2 (HER2) plays a role in the propagation of different types of cancers. It was identified in many types of cancer tissues like; breast, ovarian, lung, prostate, and… read more here.
Keywords: discovery potential; based discovery; fragment based; anticancer ... See more keywords
Discovery of Potential Antiviral Compounds against Hendra Virus by Targeting Its Receptor-Binding Protein (G) Using Computational Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27020554
Abstract: Hendra virus (HeV) belongs to the paramyxoviridae family of viruses which is associated with the respiratory distress, neurological illness, and potential fatality of the affected individuals. So far, no competitive approved therapeutic substance is available… read more here.
Keywords: discovery potential; antiviral compounds; hendra virus; receptor ... See more keywords