Articles with "discovery quinazolin" as a keyword



Photo by bermixstudio from unsplash

Discovery of 3-Quinazolin-4(3H)-on-3-yl-2,N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors.

Sign Up to like & get
recommendations!
Published in 2020 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.0c00239

Abstract: Phosphoinositide 3-kinases (PI3Ks) mediate a series of events related to cell growth, proliferation, survival, and differentiation. Overexpression of PI3Ks can lead to the dysregulation of cell homeostasis and cause tumorigenesis. In this study, rationally designed… read more here.

Keywords: pi3k; discovery quinazolin; orally active; active selective ... See more keywords