Optimal design for high-throughput screening via false discovery rate control.
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in medicine"
DOI: 10.1002/sim.8144
Abstract: High-throughput screening (HTS) is a large-scale hierarchical process in which a large number of chemicals are tested in multiple stages. Conventional statistical analyses of HTS studies often suffer from high testing error rates and soaring… read more here.
Keywords: false discovery; design; high throughput; rate ... See more keywords
Local structure learning of chain graphs with the false discovery rate control
Sign Up to like & getrecommendations! Published in 2018 at "Artificial Intelligence Review"
DOI: 10.1007/s10462-018-9669-4
Abstract: Chain graphs (CGs) containing both directed and undirected edges, offer an elegant generalisation of both Markov networks and Bayesian networks. In this paper, we propose an algorithm for local structure learning of CGs. It works… read more here.
Keywords: false discovery; chain graphs; control; structure ... See more keywords
Peak p-values and false discovery rate inference in neuroimaging
Sign Up to like & getrecommendations! Published in 2019 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2019.04.041
Abstract: Peaks are a mainstay of neuroimage analysis for reporting localization results. The current peak detection procedure in SPM12 requires a pre-threshold for approximating p-values and a false discovery rate (FDR) nominal level for inference. However,… read more here.
Keywords: values false; false discovery; inference; discovery rate ... See more keywords
Common Decoy Distributions Simplify False Discovery Rate Estimation in Shotgun Proteomics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00600
Abstract: In shotgun proteomics, false discovery rate (FDR) estimation is a necessary step to ensure the quality of accepted peptide-spectrum matches (PSMs) from a database search. Popular statistical validation tools for FDR control tend to rely… read more here.
Keywords: false discovery; common decoy; estimation; discovery rate ... See more keywords
Weighted False Discovery Rate Control in Large-Scale Multiple Testing
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Statistical Association"
DOI: 10.1080/01621459.2017.1336443
Abstract: ABSTRACT The use of weights provides an effective strategy to incorporate prior domain knowledge in large-scale inference. This article studies weighted multiple testing in a decision-theoretical framework. We develop oracle and data-driven procedures that aim… read more here.
Keywords: large scale; discovery rate; false discovery; rate ... See more keywords
Transfer Learning in Large-scale Gaussian Graphical Models with False Discovery Rate Control
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Statistical Association"
DOI: 10.1080/01621459.2022.2044333
Abstract: Transfer learning for high-dimensional Gaussian graphical models (GGMs) is studied with the goal of estimating the target GGM by utilizing the data from similar and related auxiliary studies. The similarity between the target graph and… read more here.
Keywords: gaussian graphical; false discovery; rate; graphical models ... See more keywords
Two-stage false discovery rate in microarray studies
Sign Up to like & getrecommendations! Published in 2019 at "Communications in Statistics - Theory and Methods"
DOI: 10.1080/03610926.2018.1554122
Abstract: Abstract In microarray and other genomic studies, in view of an abundance of genes, one statistical approach is to hold the family wise error rate to a prescribed limit while controlling the false discovery rate… read more here.
Keywords: discovery rate; rate; two stage; false discovery ... See more keywords
Inflated false discovery rate due to volcano plots: problem and solutions
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab053
Abstract: Abstract Motivation Volcano plots are used to select the most interesting discoveries when too many discoveries remain after application of Benjamini–Hochberg’s procedure (BH). The volcano plot suggests a double filtering procedure that selects features with… read more here.
Keywords: false discovery; volcano; usepackage; volcano plots ... See more keywords
Thresholding of cryo-EM density maps by false discovery rate control
Sign Up to like & getrecommendations! Published in 2019 at "IUCrJ"
DOI: 10.1107/s2052252518014434
Abstract: The interpretation of cryo-EM density by atomic models remains a daunting task owing to the identification of appropriate threshold levels at low signal-to-noise ratios in high-resolution shells and weak structural features. It is shown that… read more here.
Keywords: discovery rate; false discovery; cryo density;
High false discovery rate of the Architect anti‐HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing
Sign Up to like & getrecommendations! Published in 2022 at "Vox Sanguinis"
DOI: 10.1111/vox.13364
Abstract: Adequate supplies of donor blood remain a major challenge in sub‐Saharan Africa. This is exacerbated by a lack of confirmatory testing for transfusion‐transmitted infections by blood transfusion services (BTS), leading to significant blood disposal owing… read more here.
Keywords: blood donors; false discovery; blood; discovery rate ... See more keywords
The role of dispersal, selection, and timing of sampling on the false discovery rate of loci under selection during geographic range expansion.
Sign Up to like & getrecommendations! Published in 2019 at "Genome"
DOI: 10.1139/gen-2019-0004
Abstract: Identifying adaptive loci is important to understand the evolutionary potential of species undergoing range expansion. However, in expanding populations, spatial demographic processes such as allele surfing can create spatial patterns of neutral genetic variation that… read more here.
Keywords: range expansion; false discovery; selection; discovery rate ... See more keywords