Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
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DOI: 10.1021/acs.jmedchem.2c00834
Abstract: Renin is the rate-limiting enzyme in the renin-angiotensin-aldosterone system (RAAS) which regulates blood pressure and renal function and hence is an attractive target for the treatment of hypertension and cardiovascular/renal diseases. However, the development of… read more here.
Keywords: highly potent; direct renin; novel highly; discovery sph3127 ... See more keywords