Toolkit for automated and rapid discovery of structural variants.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.05.030
Abstract: Structural variations (SV) are broadly defined as genomic alterations that affect >50bp of DNA, which are shown to have significant effect on evolution and disease. The advent of high throughput sequencing (HTS) technologies and the… read more here.
Keywords: discovery structural; automated rapid; structural variants; toolkit automated ... See more keywords
Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00185
Abstract: MAGE proteins are cancer testis antigens (CTAs) that are characterized by highly conserved MAGE homology domains (MHDs) and are increasingly being found to play pivotal roles in promoting aggressive cancer types. MAGE-A4, in particular, increases… read more here.
Keywords: mage rad18; potent; mage; discovery structural ... See more keywords
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00509
Abstract: Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of… read more here.
Keywords: small molecule; discovery structural; subunit; gid4 ... See more keywords
Global Processing Styles Facilitate the Discovery of Structural Similarity
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DOI: 10.1177/0033294118787499
Abstract: This study examined whether global processing style facilitates the discovery of structural similarity. In the two experiments, the participants were presented with three stories after being primed with global or local processing through a Navon… read more here.
Keywords: discovery structural; story; structural similarity; similarity ... See more keywords