The Discovery and Structure-Activity Evaluation of (+)-Floyocidin B and Synthetic Analogs.
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DOI: 10.1002/cmdc.202100644
Abstract: Tuberculosis represents one of the ten most common courses of death worldwide and the emergence of multidrug-resistant M. tuberculosis makes the discovery of novel anti-tuberculosis active structures an urgent priority. Here, we show that (+)-floyocidin… read more here.
Keywords: activity evaluation; structure activity; structure; floyocidin ... See more keywords
Scientific revolutions, specialization and the discovery of the structure of DNA: toward a new picture of the development of the sciences
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DOI: 10.1007/s11229-017-1339-6
Abstract: In his late years, Thomas Kuhn became interested in the process of scientific specialization, which does not seem to possess the destructive element that is characteristic of scientific revolutions. It therefore makes sense to investigate… read more here.
Keywords: structure dna; toward new; specialization; scientific revolutions ... See more keywords
Discovery and Structure–Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists
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DOI: 10.1021/acs.jmedchem.2c01414
Abstract: A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists N6-cyclopentyl adenosine (CPA) and N6-cyclopentyl 5′-N-ethylcarboxamidoadenosine (CP-NECA) were synthesized, and their potency and selectivity were assessed. We observed that the most potent were… read more here.
Keywords: structure activity; discovery structure; a1r selectivity; adenosine receptor ... See more keywords
Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase.
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DOI: 10.1021/jacs.2c09412
Abstract: Terpene cyclases (TCs), extraordinary enzymes that create the structural diversity seen in terpene natural products, are traditionally divided into two classes, class I and class II. Although the structural and mechanistic features of class I… read more here.
Keywords: class sesquiterpene; class; structure mechanism; discovery structure ... See more keywords
Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications
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DOI: 10.3390/ijms24065893
Abstract: Gomesin is a cationic antimicrobial peptide which is isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana and can be produced chemically by Fmoc solid-phase peptide synthesis. Gomesin exhibits a range of biological activities,… read more here.
Keywords: structure activity; discovery structure; antimicrobial peptide; gomesin ... See more keywords