Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.020
Abstract: In this study, 12 known cycloartane triterpenoids (1-12) with four different skeletons isolated from the roots of Souliea vaginata were screened for the first time for in vitro anti-HIV activity using AZT as a standard. Among… read more here.
Keywords: synthesis novel; hiv activity; discovery synthesis; hiv ... See more keywords
Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2020.112071
Abstract: Abstract From an aqueous decoction of the traditional Chinese medicine “ban lan gen” (the Isatis indigotica root), an antiviral natural product CI - 39 was isolated as an NNRTI (non-nucleoside reverse transcriptase inhibitor) (EC50 = 3.40 μM). Its novel structure… read more here.
Keywords: discovery synthesis; isatis indigotica; indigotica root; nnrti resistant ... See more keywords
Discovery-Synthesis, Design, and Prediction of Chalcogenide Phases.
Sign Up to like & getrecommendations! Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b00188
Abstract: The discovery of new materials and their efficient syntheses is a fundamental goal of chemistry. A related objective is to identify foundational and rational approaches to enhance the art of synthesis by combining the exquisite… read more here.
Keywords: design prediction; discovery synthesis; synthesis design; chemistry ... See more keywords
Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00885
Abstract: Five novel modified linear peptides named brintonamides A-E (1-5) were discovered from a marine cyanobacterial sample collected from Brinton Channel, Florida Keys. The total synthesis of 1-5 in addition to two other structurally related analogues… read more here.
Keywords: protease; discovery synthesis; protease gpcr; cancer ... See more keywords
Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc03399d
Abstract: BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been… read more here.
Keywords: first selective; discovery synthesis; bag3; synthesis first ... See more keywords
Review of α-nucleosides: from discovery, synthesis to properties and potential applications
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra01399g
Abstract: A systematic summary of the discovery, synthesis, properties and potential applications of α-nucleosides and their derivatives. read more here.
Keywords: properties potential; review nucleosides; potential applications; synthesis properties ... See more keywords
Understanding, discovery, and synthesis of 2D materials enabled by machine learning.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d1cs00503k
Abstract: Machine learning (ML) is becoming an effective tool for studying 2D materials. Taking as input computed or experimental materials data, ML algorithms predict the structural, electronic, mechanical, and chemical properties of 2D materials that have… read more here.
Keywords: synthesis materials; machine learning; discovery synthesis; materials enabled ... See more keywords