Articles with "discovery tenapanor" as a keyword



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Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3

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Published in 2022 at "ACS Medicinal Chemistry Letters"

DOI: 10.1021/acsmedchemlett.2c00037

Abstract: We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium… read more here.

Keywords: tenapanor first; exchanger isoform; first class; minimally systemic ... See more keywords