Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity
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DOI: 10.1021/acs.jcim.9b01133
Abstract: Microtubules (MT) are cytoskeletal polymers of αβ-tubulin dimers that play a critical role in many cellular functions. Diverse antimitotic drugs bind to MT and disrupt their dynamics acting as MT stabilizing or destabilizing agents. The… read more here.
Keywords: rational discovery; based rational; discovery vitro; discovery ... See more keywords