How Peptides Bind to PSD-95/Discs-Large/ZO-1 Domains.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.1c01140
Abstract: PSD-95/discs-large/ZO-1 (PDZ) domains form a large family of adaptor proteins that bind to the C-terminal tails of their binding partner proteins. Via extensive molecular dynamics simulations and alchemical free energy calculations, we characterized the binding… read more here.
Keywords: peptides bind; discs large; free energy; psd discs ... See more keywords
The human Discs large protein (Dlg1) interacts with and maintains Connexin 43 at the plasma membrane in keratinocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.259984
Abstract: Gap junction channels, composed of connexins, allow direct cell-to-cell communication. Connexin 43 (Cx43) is widely expressed in tissues, including the epidermis. In a previous study of human papillomavirus-positive cervical epithelial tumour cells, we identified Cx43… read more here.
Keywords: dlg1; cx43; discs large; membrane ... See more keywords