Co‐Delivery of Disease Associated Peptide and Rapamycin via Acetalated Dextran Microparticles for Treatment of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700022
Abstract: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. While 2.5 million people are affected by MS worldwide, there is no cure other than ameliorating the symptoms through broad immune suppression, which… read more here.
Keywords: treatment; acetalated dextran; disease; multiple sclerosis ... See more keywords
Prediction of disease‐associated functional variants in noncoding regions through a comprehensive analysis by integrating datasets and features
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24203
Abstract: One of the greatest challenges in human genetics is deciphering the link between functional variants in noncoding sequences and the pathophysiology of complex diseases. To address this issue, many methods have been developed to sort… read more here.
Keywords: variants noncoding; prediction disease; functional variants; disease associated ... See more keywords
Computational Screening and Exploration of Disease‐Associated Genes in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25806
Abstract: Alzheimer's is a neurodegenerative disease affecting large populations worldwide characterized mainly by progressive loss of memory along with various other symptoms. The foremost cause of the disease is still unclear, however various mechanisms have been… read more here.
Keywords: screening exploration; disease; computational screening; disease associated ... See more keywords
Molecular and clinical characterization of Thai patients with achromatopsia: identification of three novel disease-associated variants in the CNGA3 and CNGB3 genes
Sign Up to like & getrecommendations! Published in 2020 at "International Ophthalmology"
DOI: 10.1007/s10792-020-01559-2
Abstract: Purpose Achromatopsia (ACHM) is an autosomal recessive cone disorder characterized by pendular nystagmus, photophobia, reduced visual acuity, and partial or total absence of color vision. Mutations in six genes ( CNGA3 , CNGB3 , GNAT2… read more here.
Keywords: molecular clinical; cnga3 cngb3; disease; thai patients ... See more keywords
A novel disease-associated nucleic acid sensing platform based on split DNA-scaffolded sliver nanocluster.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338734
Abstract: Disease-associated nucleic acids, such as DNAs and miRNAs, are important biomarkers for the diagnosis, prognosis and treatment guidance of human diseases. Therefore, the accurate and sensitive detection of nucleic acid is of great significance for… read more here.
Keywords: associated nucleic; dna; platform; disease ... See more keywords
Molecular and structural characterization of disease-associated APE1 polymorphisms.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102867
Abstract: Under conditions of oxidative stress, reactive oxygen species (ROS) continuously assault the structure of DNA resulting in oxidation and fragmentation of the nucleobases. When the nucleobase structure is altered, its base-pairing properties may also be… read more here.
Keywords: characterization; dna; disease; disease associated ... See more keywords
Novel DCC variants in congenital mirror movements and evaluation of disease-associated missense variants.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2018.01.010
Abstract: Congenital mirror movements (CMM) are involuntary movements of one side of the body that mirror intentional movements of the other side. Heterozygous missense, frameshift and nonsense variants and small intragenic deletions in DCC cause CMM,… read more here.
Keywords: missense variants; mirror movements; dcc variants; congenital mirror ... See more keywords
Celiac disease associated snp rs17810546 is located in a gene silencing region.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144165
Abstract: GWAS studies have identified variant rs17810546 in a non-coding region on chromosome 3 as a risk factor for several auto-immune diseases, including Celiac Disease. In silico analysis reveals that this variant is located in a… read more here.
Keywords: rs17810546; celiac disease; disease associated; gene ... See more keywords
Advances in Perianal Disease Associated with Crohn's Disease-Evolving Approaches.
Sign Up to like & getrecommendations! Published in 2019 at "Gastrointestinal endoscopy clinics of North America"
DOI: 10.1016/j.giec.2019.02.011
Abstract: Perianal diseases, common complications of Crohn's disease, are difficult to diagnose/manage. Patients with perianal Crohn's disease suffer from persistent pain and drainage, recurrent perianal sepsis, impaired quality of life, and financial burden. Conventional medical and… read more here.
Keywords: associated crohn; advances perianal; perianal disease; disease ... See more keywords
Complete functional characterization of disease-associated genetic variants in the complement factor H gene.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.07.015
Abstract: Genetic analyses in atypical hemolytic uremic syndrome (aHUS) and C3-glomerulopathy (C3G) patients have provided an excellent understanding of the genetic component of the disease and informed genotype-phenotype correlations supporting an individualized approach to patient management… read more here.
Keywords: functional characterization; disease; complete functional; disease associated ... See more keywords
Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression
Sign Up to like & getrecommendations! Published in 2022 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2022.111635
Abstract: Raised expression of the receptor for advanced-glycation endproducts (RAGE) in cardiac tissue is well-known in the elderly, in diabetes mellitus, and after acute cardiac infarction or ischemia/reperfusion injuries. RAGE and its binding partners affect the… read more here.
Keywords: associated rage; disease associated; rage; sex ... See more keywords