Long-term control of Paget’s disease of bone with low-dose, once-weekly, oral bisphosphonate preparations, in a “real world” setting
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine"
DOI: 10.1007/s12020-019-01967-0
Abstract: PURPOSE Bisphosphonates are the mainstay of the treatment of Paget's disease of bone (PDB). Clinical practice guidelines recommend treatment with intravenous zoledronic acid or high-dose oral nitrogen bisphosphonates (N-BPs). We present our long-term experience treating… read more here.
Keywords: real world; week; disease bone; long term ... See more keywords
A likely cranial osteodystrophy (Paget’s disease of bone) in a Precolumbian, Mesoamerican stone sculpture
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0612-3
Abstract: This short note illustrates facial and head features found in a stone sculpture of the ancient, Precolumbian period in a temple of the Mayan city of Copan (Honduras). The authors believe that this observation may… read more here.
Keywords: stone sculpture; disease bone; paget disease;
Catastrophic failure of cup revision hip arthroplasty due to undiagnosed Paget disease of bone: A case report
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2020.09.101
Abstract: Highlights • Paget disease of the bone, while exceptionally rare in Asian populations, may be responsible for the loosening of arthroplasty components.• The correct diagnosis of Paget disease of the bone was delayed, resulting in… read more here.
Keywords: bone; disease bone; paget disease; case ... See more keywords
Molecular insights into an ancient form of Paget’s disease of bone
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1820556116
Abstract: Significance We identify an ancient and atypical form of Paget’s disease of bone (PDB) in a collection of medieval skeletons exhibiting unusually extensive pathological changes, high disease prevalence, and low age-at-death estimations. Proteomic analysis of… read more here.
Keywords: disease bone; form paget; disease; pdb ... See more keywords
Interleukin-6 trans-signaling and pathological low back pain in patients with Paget disease of bone
Sign Up to like & getrecommendations! Published in 2018 at "PAIN"
DOI: 10.1097/j.pain.0000000000001260
Abstract: Abstract The interleukin (IL)-6 biological system plays a key role in the pathogenesis of Paget disease (PD) of bone and pathological bone pain. Bone pain, particularly in the lower back region, is the most frequent… read more here.
Keywords: disease bone; back pain; low back; bone ... See more keywords
AB0891 HYPERURICEMIA AND GOUT IN PATIENTS WITH PAGET’S DISEASE OF BONE
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.7534
Abstract: Background Hyperuricemia and gout has been described as metabolic complications in patients with more extensive Paget’s disease, with a very variable prevalence. However, there is no data about fluctuations of uric acid levels asociated with… read more here.
Keywords: hyperuricemia gout; disease bone; treatment; gout ... See more keywords
Possible role for glucagon in the control of Paget’s disease of bone
Sign Up to like & getrecommendations! Published in 2019 at "Postgraduate Medical Journal"
DOI: 10.1136/postgradmedj-2018-136193
Abstract: Paget’s disease of bone is characterised by overactive osteoclasts that resorb bone at a higher rate than normal. Osteoblasts attempt to repair the damage by laying down new bone which in turn is resorbed leaving… read more here.
Keywords: glucagon; disease bone; disease; bone ... See more keywords
Update on the pathogenesis and genetics of Paget’s disease of bone
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.932065
Abstract: Studies over the past two decades have led to major advances in the pathogenesis of Paget’s disease of bone (PDB) and particularly on the role of genetic factors. Germline mutations of different genes have been… read more here.
Keywords: pdb; disease bone; pathogenesis; biology ... See more keywords
Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget’s Disease of Bone
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.850462
Abstract: Objective To evaluate the clinical features of sporadic Paget’s disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease. Methods Clinical characteristics, biochemical indices, bone turnover markers and radiographic… read more here.
Keywords: bone; disease bone; gene; clinical characteristics ... See more keywords
Newly Diagnosed Monostotic Paget’s Disease of Bone during Living Kidney Donor Candidate Evaluation
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020401
Abstract: The popularity of living-donor organ donation has increased recently as an alternative to deceased-organ donation due to the growing need for organs and a shortage of deceased-donor organs. This procedure requires an in-depth health assessment… read more here.
Keywords: living kidney; bone; disease bone; newly diagnosed ... See more keywords
Updates on Paget’s Disease of Bone
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology and Metabolism"
DOI: 10.3803/enm.2022.1575
Abstract: Paget’s disease of the bone is a prevalent bone disease characterized by disorganized bone remodeling; however, it is comparatively uncommon in East Asian countries, including China, Japan, and Korea. The exact cause still remains unknown.… read more here.
Keywords: disease; bone; updates paget; disease bone ... See more keywords