Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
Sign Up to like & getrecommendations! Published in 2022 at "Nature Neuroscience"
DOI: 10.1038/s41593-021-00999-y
Abstract: The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain tissues to reveal new AD-related protein co-expression modules… read more here.
Keywords: brain; observed rna; module; disease ... See more keywords
A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer’s disease brain
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac023
Abstract: Abstract Aqueously soluble oligomers of amyloid-β peptide may be the principal neurotoxic forms of amyloid-β in Alzheimer’s disease, initiating downstream events that include tau hyperphosphorylation, neuritic/synaptic injury, microgliosis and neuron loss. Synthetic oligomeric amyloid-β has… read more here.
Keywords: alzheimer disease; oligomeric amyloid; disease brain; amyloid ... See more keywords
Neurodegenerative disease of the brain: a survey of interdisciplinary approaches
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0406
Abstract: Neurodegenerative diseases of the brain pose a major and increasing global health challenge, with only limited progress made in developing effective therapies over the last decade. Interdisciplinary research is improving understanding of these diseases and… read more here.
Keywords: survey interdisciplinary; disease brain; brain; interdisciplinary approaches ... See more keywords
Abstract MP31: Peripheral Vascular Dysfunction In A Model Of Small Vessel Disease Of The Brain (CADASIL) Involves Impaired Redox-sensitive Cyclic GMP/PKG Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.mp31
Abstract: CADASIL, a monogenic condition due to Notch3 mutations, is a very aggressive small vessel disease of the brain resulting in premature vascular dementia and stroke. Changes in cerebral vessels inclu... read more here.
Keywords: small vessel; cadasil; disease brain; vessel disease ... See more keywords
Abstract 151: Intracranial Atherosclerotic Disease and Brain Amyloid Deposition: The ARIC Study
Sign Up to like & getrecommendations! Published in 2018 at "Stroke"
DOI: 10.1161/str.49.suppl_1.151
Abstract: Background: Increasing evidence points to intracranial atherosclerosis as a risk factor not only for stroke but also for dementia, but whether it is linked to Alzheimer’s disease-specific pathology... read more here.
Keywords: abstract 151; intracranial atherosclerotic; disease; disease brain ... See more keywords