A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110685
Abstract: Cellular heterogeneity of aortic valves complicates the mechanistic evaluation of the calcification processes in calcific aortic valve disease (CAVD), and animal disease models are lacking. In this study, we identify a disease-driver population (DDP) within… read more here.
Keywords: calcific aortic; profiling; cell; disease ... See more keywords
Graves’ disease as a driver of depression: a mechanistic insight
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1162445
Abstract: Graves’ disease (GD) is characterized by diffuse enlargement and overactivity of the thyroid gland, which may be accompanied by other physical symptoms. Among them, depression can dramatically damage patients’ quality of life, yet its prevalence… read more here.
Keywords: driver depression; mechanistic insight; disease driver; depression ... See more keywords