P845 Vedolizumab induces endoscopic healing uniformly irrespective of disease location: post-hoc analysis of the LOVE-CD trial
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DOI: 10.1093/ecco-jcc/jjad212.0975
Abstract: Vedolizumab (VDZ) is a gut-selective anti–α4β7-integrin monoclonal antibody approved for the treatment of Crohn's disease (CD). We performed a post-hoc analysis of the LOVE-CD trial to evaluate the effect of disease location on endoscopic healing.… read more here.
Keywords: disease; itt nri; analysis; endoscopic remission ... See more keywords
OP30 Dissecting the genetic basis of clinical phenotype heterogeneity within IBD in more than 63,000 IBD patients
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DOI: 10.1093/ecco-jcc/jjae190.0030
Abstract: More than 200 genetic variants associated with Inflammatory Bowel Disease (IBD) susceptibility are known but few large-scale studies have been performed to examine the genetics basis of the heterogeneity of clinical phenotypes in IBD, including… read more here.
Keywords: disease; clinical phenotypes; genetics; disease location ... See more keywords
P0702 Efficacy of subcutaneous infliximab maintenance therapy according to disease location in patients with moderate-to-severe Crohn’s disease: A post hoc analysis of the Phase 3 LIBERTY-CD study
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DOI: 10.1093/ecco-jcc/jjae190.0876
Abstract: The impact of targeted therapies for patients (pts) with Crohn’s disease (CD) differs by disease location.1 Using data from the Phase 3 LIBERTY-CD study, which demonstrated the superiority of subcutaneous (SC) infliximab (IFX) maintenance therapy… read more here.
Keywords: location; disease; disease location; maintenance therapy ... See more keywords
Lens Aquaporins in Health and Disease: Location is Everything!
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DOI: 10.3389/fphys.2022.882550
Abstract: Cataract and presbyopia are the leading cause of vision loss and impaired vision, respectively, worldwide. Changes in lens biochemistry and physiology with age are responsible for vision impairment, yet the specific molecular changes that underpin… read more here.
Keywords: disease location; physiology; lens aquaporins; location everything ... See more keywords