Alzheimer’s disease: many failed trials, so where do we go from here?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2020-001297
Abstract: Alzheimer’s disease (AD) is a neurodegenerative brain disorder associated with relentlessly progressive cognitive impairment and memory loss. AD pathology proceeds for decades before cognitive deficits become clinically apparent, opening a window for preventative therapy. Imbalance… read more here.
Keywords: medicine; failed trials; disease many; alzheimer disease ... See more keywords
Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020002953
Abstract: The surge of human genetic information, enabled by increasingly facile and economically feasible genomic technologies, has accelerated discoveries on the relationship of germline genetic variation to hematologic diseases. For example, germline variation in GATA2, encoding… read more here.
Keywords: gata2 mutations; mutations hematologic; disease many; gata2 ... See more keywords
One Disease, Many Genes: Implications for the Treatment of Osteopetroses
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00085
Abstract: Osteopetrosis is a condition characterized by increased bone mass due to defects in osteoclast function or formation. In the last decades, the molecular dissection of osteopetrosis has unveiled a plethora of molecular players responsible for… read more here.
Keywords: many genes; implications treatment; disease many; one disease ... See more keywords