In silico disease model: from simple networks to complex diseases
Sign Up to like & getrecommendations! Published in 2020 at "Animal Biotechnology"
DOI: 10.1016/b978-0-12-811710-1.00020-3
Abstract: Abstract In this chapter we consider in silico modeling of diseases starting from some simple to some complex (and mathematical) concepts. Examples and applications of in silico modeling for some important categories of diseases (such… read more here.
Keywords: silico disease; model simple; disease model; simple networks ... See more keywords
A silk peptide fraction restores cognitive function in AF64A‐induced Alzheimer disease model rats by increasing expression of choline acetyltransferase gene
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.11.008
Abstract: Abstract This study investigated the effects of a silk peptide fraction obtained by incubating silk proteins with Protease N and Neutrase (SP‐NN) on cognitive dysfunction of Alzheimer disease model rats. In order to elucidate underlying… read more here.
Keywords: disease model; alzheimer disease; model rats; expression ... See more keywords
Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2018.12.009
Abstract: INTRODUCTION Acute intermittent porphyria (AIP) is characterized by hepatic over-production of the heme precursors when aminolevulinic acid (ALA)-synthase 1 is induced by endogenous or environmental factors. The aim of this study was to develop a… read more here.
Keywords: acute intermittent; intermittent porphyria; disease model; acute attacks ... See more keywords
Novel Small-Molecule Inhibitor of NLRP3 Inflammasome Reverses Cognitive Impairment in an Alzheimer's Disease Model.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00831
Abstract: Aberrant activation of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays an essential role in multiple diseases, including Alzheimer's disease (AD) and psoriasis. We report a novel small-molecule inhibitor, NLRP3-inhibitory compound 7 (NIC7),… read more here.
Keywords: disease; alzheimer disease; disease model; model ... See more keywords
Scaling up disease model discovery
Sign Up to like & getrecommendations! Published in 2017 at "Lab Animal"
DOI: 10.1038/laban.1342
Abstract: data and ranks their mutant lines as models for human diseases. “The goal is to use phenotype mapping along with whole genome variant prioritization and filtering to land on the most likely causative variant along… read more here.
Keywords: disease model; mouse genome; disease; impc ... See more keywords
Reversing Parkinson Disease Model with in situ Converted Nigral Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2388-4
Abstract: Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra 1 . Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease. While most treatment strategies aim to… read more here.
Keywords: disease model; reversing parkinson; disease; parkinson disease ... See more keywords
The Dynamics and Optimal Control of a Hand-Foot-Mouth Disease Model
Sign Up to like & getrecommendations! Published in 2018 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2018/9254794
Abstract: We build and study the transmission dynamics of a hand-foot-mouth disease model with vaccination. The reproduction number is given, the existence of equilibria is obtained, and the global stability of disease-free equilibrium is proved by… read more here.
Keywords: disease model; foot mouth; disease; hand foot ... See more keywords
Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s161944
Abstract: Background Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that lacks any disease-modifying drug for the prevention and treatment. Edaravone (EDR), an approved free radical scavenger, has proven to have potential against AD by targeting… read more here.
Keywords: disease model; alzheimer disease; safety; disease ... See more keywords
The abdominal aortic aneurysm-related disease model based on machine learning predicts immunity and m1A/m5C/m6A/m7G epigenetic regulation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1131957
Abstract: Introduction: Abdominal aortic aneurysms (AAA) are among the most lethal non-cancerous diseases. A comprehensive analysis of the AAA-related disease model has yet to be conducted. Methods: Weighted correlation network analysis (WGCNA) was performed for the… read more here.
Keywords: aaa related; related disease; abdominal aortic; disease model ... See more keywords
Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson’s Disease Model of Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179572
Abstract: Mitochonic Acid 5 (MA-5) enhances mitochondrial ATP production, restores fibroblasts from mitochondrial disease patients and extends the lifespan of the disease model “Mitomouse”. Additionally, MA-5 interacts with mitofilin and modulates the mitochondrial inner membrane organizing… read more here.
Keywords: improves duchenne; mitochonic acid; disease; caenorhabditis elegans ... See more keywords
Disease model organism for Parkinson disease: Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2019 at "BMB Reports"
DOI: 10.5483/bmbrep.2019.52.4.204
Abstract: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20… read more here.
Keywords: disease model; parkinson disease; model organism; model ... See more keywords