Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2021.106956
Abstract: Göttingen Minipigs show several anatomical, physiological, and pathogenetical similarities to humans and serve an important role in translational studies for example as large animal models of disease. In recent years, the number of transgenic Göttingen… read more here.
Keywords: genisyst; disease; generation; disease modelling ... See more keywords
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07594-z
Abstract: The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed… read more here.
Keywords: organoid derived; disease modelling; podocyte; cell ... See more keywords
High content organelle trafficking enables disease state profiling as powerful tool for disease modelling
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Data"
DOI: 10.1038/sdata.2018.241
Abstract: Neurodegenerative diseases pose a complex field with various neuronal subtypes and distinct differentially affected intra-neuronal compartments. Modelling of neurodegeneration requires faithful in vitro separation of axons and dendrites, their distal and proximal compartments as well… read more here.
Keywords: organelle trafficking; disease; disease modelling; high content ... See more keywords
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.210333
Abstract: Non-clinical models to study metabolism including animal models and cell assays are often limited in terms of species translatability and predictability of human biology. This field urgently requires a push towards more physiologically accurate recapitulations… read more here.
Keywords: organ chips; disease modelling; multi organ; metabolism ... See more keywords
AI for infectious disease modelling and therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789811232701_0009
Abstract: AI for infectious disease modelling and therapeutics is an emerging area that leverages new computational approaches and data in this area. Genomics, proteomics, biomedical literature, social media, and other resources are proving to be critical… read more here.
Keywords: modelling therapeutics; disease modelling; infectious disease;
Editorial: Advances in platforms for disease modelling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1190492
Abstract: Laboratorios de Investigación Aplicada en Neurociencias (LIAN-CONICET), Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (Fleni), Buenos Aires, Argentina, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, Delhi,… read more here.
Keywords: editorial advances; platforms disease; hepatology; gastroenterology ... See more keywords
Generation of an Open-Access Patient-Derived iPSC Biobank for Amyotrophic Lateral Sclerosis Disease Modelling
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14051108
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting the upper and lower motor neurons, causing patients to lose control over voluntary movement, and leading to gradual paralysis and death. There is no cure… read more here.
Keywords: ipsc biobank; disease; lateral sclerosis; open access ... See more keywords
A Systematic Map of the Research on Disease Modelling for Agricultural Crops Worldwide
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11060724
Abstract: In this work, we developed a systematic map to identify and catalogue the literature pertaining to disease modelling for agricultural crops worldwide. Searches were performed in 2021 in the Web of Science and Scopus for… read more here.
Keywords: disease; systematic map; modelling agricultural; agricultural crops ... See more keywords