Timing behavior in genetic murine models of neurological and psychiatric diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental brain research"
DOI: 10.1007/s00221-020-06021-4
Abstract: How timing behavior is altered in different neurodevelopmental and neurodegenerative disorders is a contemporary research question. Genetic murine models (GMM) that offer high construct validity also serve as useful tools to investigate this question. But… read more here.
Keywords: disease models; murine models; genetic murine; timing behavior ... See more keywords
Development of vascular disease models to explore disease causation and pathomechanisms of rare vascular diseases
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-022-00925-9
Abstract: As the field of medicine is striving forward heralded by a new era of next-generation sequencing (NGS) and integrated technologies such as bioprinting and biological material development, the utility of rare monogenetic vascular disease modeling… read more here.
Keywords: vascular diseases; rare vascular; medicine; vascular disease ... See more keywords
Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microbiology"
DOI: 10.1007/s12275-017-7029-8
Abstract: A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak.… read more here.
Keywords: bunyavirus etiology; etiology; hemorrhagic fever; disease models ... See more keywords
Imaging the execution phase of neuroinflammatory disease models
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.112968
Abstract: In vivo imaging of the rodent spinal cord has advanced our understanding of how resident cells of the central nervous system (CNS) respond to neuroinflammation. By combining two-photon imaging and experimental autoimmune encephalomyelitis (EAE), the… read more here.
Keywords: disease models; disease; phase neuroinflammatory; imaging execution ... See more keywords
Reproduction numbers of infectious disease models.
Sign Up to like & getrecommendations! Published in 2017 at "Infectious Disease Modelling"
DOI: 10.1016/j.idm.2017.06.002
Abstract: This primer article focuses on the basic reproduction number, ℛ0 , for infectious diseases, and other reproduction numbers related to ℛ0 that are useful in guiding control strategies. Beginning with a simple population model, the… read more here.
Keywords: numbers infectious; infectious disease; reproduction numbers; reproduction ... See more keywords
A review and agenda for integrated disease models including social and behavioural factors.
Sign Up to like & getrecommendations! Published in 2021 at "Nature human behaviour"
DOI: 10.1038/s41562-021-01136-2
Abstract: Social and behavioural factors are critical to the emergence, spread and containment of human disease, and are key determinants of the course, duration and outcomes of disease outbreaks. Recent epidemics of Ebola in West Africa… read more here.
Keywords: integrated disease; behavioural factors; disease models; disease ... See more keywords
Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53876-x
Abstract: Implementation of in vivo high-resolution micro-computed tomography (µCT), a powerful tool for longitudinal analysis of murine lung disease models, is hampered by the lack of data on cumulative low-dose radiation effects on the investigated disease… read more here.
Keywords: computed tomography; murine; disease models; disease ... See more keywords
Knock-out iPSCs for disease and therapy modeling of IL-10 associated primary immunodeficiencies.
Sign Up to like & getrecommendations! Published in 2020 at "Human gene therapy"
DOI: 10.1089/hum.2020.235
Abstract: Samples from patients with rare diseases, such as primary immunodeficiencies, are often limited, which hampers careful analysis of the pathomechanisms involved in immune cell dysregulation. To overcome this issue, induced pluripotent stem cells (iPSCs) represent… read more here.
Keywords: knock; cytokine; disease models; disease ... See more keywords
Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvy090
Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity. There is considerable inter-patient variability in the pathologic processes that promote AF, and this variability likely has a significant genetic… read more here.
Keywords: atrial fibrillation; disease models; stem cell; role ... See more keywords
Comprehensive autophagy evaluation in cardiac disease models
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvz233
Abstract: Abstract Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the… read more here.
Keywords: cardiac disease; comprehensive autophagy; evaluation cardiac; disease models ... See more keywords
Plant disease models and forecasting: changes in principles and applications over the last 50 years.
Sign Up to like & getrecommendations! Published in 2023 at "Phytopathology"
DOI: 10.1094/phyto-10-22-0362-kd
Abstract: This review gives a perspective of selected advances made since the middle of the 20th century in plant disease modelling, and the associated increase in the number of models published during that time frame. This… read more here.
Keywords: last years; plant disease; disease; disease models ... See more keywords