Riociguat in systemic sclerosis: a potential for disease modification.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the rheumatic diseases"
DOI: 10.1136/annrheumdis-2020-218180
Abstract: We read with great interest the results of the recently published Riociguat Safety and Efficacy in Systemic Sclerosis (RISE-SSc) trial1 and believe that additional analyses could further elucidate the role of riociguat in systemic sclerosis… read more here.
Keywords: sclerosis; disease modification; sclerosis potential; riociguat systemic ... See more keywords
Early intervention in Crohn’s disease: towards disease modification trials
Sign Up to like & getrecommendations! Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2017-314519
Abstract: Crohn’s disease (CD) is a chronic progressive destructive inflammatory bowel disease. As in rheumatoid arthritis, there is increasing evidence that early treatment initiation with disease-modifying agents, such as biological drugs, may lead to complete disease… read more here.
Keywords: disease modification; early intervention; disease; modification trials ... See more keywords
Disease modification and biomarker development in Parkinson disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurology"
DOI: 10.1212/wnl.0000000000009107
Abstract: A fundamental question in advancing Parkinson disease (PD) research is whether it represents one disorder or many. Does each genetic PD inform a common pathobiology or represent a unique entity? Do the similarities between genetic… read more here.
Keywords: biomarker development; modification biomarker; disease modification; parkinson disease ... See more keywords
Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11010170
Abstract: Oxidative stress and neuroinflammation are common bases for disease onset and progression in many neurodegenerative diseases. In Parkinson disease, which is characterized by the degeneration of dopaminergic neurons resulting in dopamine depletion, the pathogenesis differs… read more here.
Keywords: disease; parkinson disease; astrocytes microglia; disease modification ... See more keywords