Robust disease module mining via enumeration of diverse prize-collecting Steiner trees
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab876
Abstract: MOTIVATION Disease module mining methods (DMMMs) extract subgraphs that constitute candidate disease mechanisms from molecular interaction networks such as protein-protein interaction (PPI) networks. Irrespective of the employed models, DMMMs typically include non-robust steps in their… read more here.
Keywords: robust disease; disease; disease module; module mining ... See more keywords
A statistical physics approach for disease module detection
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276690.122
Abstract: Extensive evidence indicates that the pathobiological processes of a complex disease are associated with perturbation within specific disease neighborhoods of the human protein-protein interaction (PPI) network (a.k.a. the interactome), often referred to as the disease… read more here.
Keywords: physics; disease; disease module; module detection ... See more keywords
Constructing Disease Similarity Networks Based on Disease Module Theory
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2018.2817624
Abstract: Quantifying the associations between diseases is now playing an important role in modern biology and medicine. Actually discovering associations between diseases could help us gain deeper insights into pathogenic mechanisms of complex diseases, thus could… read more here.
Keywords: disease module; biology; module theory; disease similarity ... See more keywords