Deriving disease modules from the compressed transcriptional space embedded in a deep autoencoder
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14666-6
Abstract: Disease modules in molecular interaction maps have been useful for characterizing diseases. Yet biological networks, that commonly define such modules are incomplete and biased toward some well-studied disease genes. Here we ask whether disease-relevant modules… read more here.
Keywords: modules compressed; disease; disease modules; deep autoencoder ... See more keywords
Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99721-y
Abstract: This analysis presents a systematic evaluation of the extent of therapeutic opportunities that can be obtained from drug repurposing by connecting drug targets with disease genes. When using FDA-approved indications as a reference level we… read more here.
Keywords: network; module; drug repurposing; drug ... See more keywords
A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-07935-1
Abstract: Background There exist few, if any, practical guidelines for predictive and falsifiable multi-omic data integration that systematically integrate existing knowledge. Disease modules are popular concepts for interpreting genome-wide studies in medicine but have so far… read more here.
Keywords: module; disease modules; multi omic; risk factors ... See more keywords
Disturbed ribosome-related modules were associated with Kawasaki disease.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201810_16052
Abstract: OBJECTIVE Kawasaki disease (KD) is an acute vasculitis in young children, with ambiguous etiology. Early diagnosis will decrease the risk of coronary artery aneurysms and contributes to the favourable prognosis. This work aimed to identify… read more here.
Keywords: disturbed ribosome; disease; kawasaki disease; ribosome related ... See more keywords
Conserved Disease Modules Extracted From Multilayer Heterogeneous Disease and Gene Networks for Understanding Disease Mechanisms and Predicting Disease Treatments
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00745
Abstract: Disease relationship studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis, and drug development are important. Traditional approaches consider one type of disease data or aggregating multiple types of disease data into a single… read more here.
Keywords: modules extracted; network; disease; extracted multilayer ... See more keywords