Serum Neurofilament Light and Clinical Biomarkers for Disease Staging in Huntington's Disease
Sign Up to like & getrecommendations! Published in 2024 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13993
Abstract: Recently, the Huntington ’ s Disease (HD) Integrated Staging System (HD-ISS) was developed as a new framework to standardize clinical research for HD. 1 Nevertheless, HD patients can show variable performance in certain tests at… read more here.
Keywords: disease; clinical biomarkers; neurofilament light; huntington disease ... See more keywords
Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27427
Abstract: Objectives: In order to evaluate the influence of the genetic load of 49 genetic variants known to be associated with PD on the age at onset as well as on clinical outcome parameters. read more here.
Keywords: polygenic load; disease; disease onset; load earlier ... See more keywords
Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-024-02086-y
Abstract: Corticosteroids are recommended only for induction of remission in inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). This study aimed to evaluate the change in pharmacologic treatment use, particularly systemic corticosteroids,… read more here.
Keywords: use; disease onset; disease; surgery rate ... See more keywords
Long-term effects of SARS-CoV-2 infection in patients with and without chemosensory disorders at disease onset: a psychophysical and magnetic resonance imaging exploratory study
Sign Up to like & getrecommendations! Published in 2024 at "Neurological Sciences"
DOI: 10.1007/s10072-024-07429-4
Abstract: A preserved sense of smell and taste allows us to understand many environmental “messages” and results in meaningfully improvements to quality of life. With the COVID-19 pandemic, it became clear how important these senses are… read more here.
Keywords: resonance imaging; group; exploratory study; disease onset ... See more keywords
Pregnancy and IBD: Timing Is Everything
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4498-x
Abstract: Since the peak age of reproduction coincides with the peak incidence of inflammatory bowel disease (IBD), many female patients worry about the effect of pregnancy on disease activity, the effect of IBD on pregnancy and… read more here.
Keywords: pregnancy; disease; disease onset; disease activity ... See more keywords
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "IBRO Reports"
DOI: 10.1016/j.ibror.2019.01.005
Abstract: Highlights • Th2-type cytokine IL-33 delayed the disease onset of female SOD1-G93 A transgenic ALS mice.• IL-33 decreased the proportion of T cells in the spleens and lymph nodes of female mice.• IL-33 decreased astrocytic activation… read more here.
Keywords: long term; treatment; astrocytic activation; disease onset ... See more keywords
NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.102833
Abstract: The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients… read more here.
Keywords: nfl levels; disease onset; levels predominantly; disorders nfl ... See more keywords
SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Translational Gastroenterology"
DOI: 10.1038/s41424-018-0069-5
Abstract: Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and… read more here.
Keywords: clinical outcomes; spink1 prss1; ctrc cftr; prss1 ctrc ... See more keywords
Disease onset goes with its gut in RA
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0436-y
Abstract: Nature reviews | Rheumatology Reducing intestinal permeability in the period before clinical arthritis ... delayed disease onset The mucosal origins hypothesis postulates that, in rheumatoid arthritis (RA), disease begins to develop at mucosal sites such… read more here.
Keywords: intestinal permeability; disease; disease onset; rheumatology ... See more keywords
Delaying the first grapevine fungicide application reduces exposure on operators by half
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62954-4
Abstract: Downy mildew is a severe disease of grapevines treated by repeated fungicide applications during the growing season. The impact of these treatments on human health is currently under scrutiny. Fungicide application long before disease onset… read more here.
Keywords: delaying first; exposure; fungicide; disease onset ... See more keywords
Semiparametric joint modeling for biomarker trajectory before disease onset.
Sign Up to like & getrecommendations! Published in 2025 at "Biometrics"
DOI: 10.1093/biomtc/ujaf064
Abstract: Understanding how biomarkers change in relation to disease pathogenesis is a key area in biomedical research. We propose a semiparametric joint model to analyze the temporal evolution of biomarkers prior to the onset of disease.… read more here.
Keywords: disease; time; disease onset; semiparametric joint ... See more keywords