Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27427
Abstract: Objectives: In order to evaluate the influence of the genetic load of 49 genetic variants known to be associated with PD on the age at onset as well as on clinical outcome parameters. read more here.
Keywords: polygenic load; disease; disease onset; load earlier ... See more keywords
Pregnancy and IBD: Timing Is Everything
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4498-x
Abstract: Since the peak age of reproduction coincides with the peak incidence of inflammatory bowel disease (IBD), many female patients worry about the effect of pregnancy on disease activity, the effect of IBD on pregnancy and… read more here.
Keywords: pregnancy; disease; disease onset; disease activity ... See more keywords
Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "IBRO Reports"
DOI: 10.1016/j.ibror.2019.01.005
Abstract: Highlights • Th2-type cytokine IL-33 delayed the disease onset of female SOD1-G93 A transgenic ALS mice.• IL-33 decreased the proportion of T cells in the spleens and lymph nodes of female mice.• IL-33 decreased astrocytic activation… read more here.
Keywords: long term; treatment; astrocytic activation; disease onset ... See more keywords
NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.102833
Abstract: The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients… read more here.
Keywords: nfl levels; disease onset; levels predominantly; disorders nfl ... See more keywords
SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Translational Gastroenterology"
DOI: 10.1038/s41424-018-0069-5
Abstract: Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and… read more here.
Keywords: clinical outcomes; spink1 prss1; ctrc cftr; prss1 ctrc ... See more keywords
Disease onset goes with its gut in RA
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0436-y
Abstract: Nature reviews | Rheumatology Reducing intestinal permeability in the period before clinical arthritis ... delayed disease onset The mucosal origins hypothesis postulates that, in rheumatoid arthritis (RA), disease begins to develop at mucosal sites such… read more here.
Keywords: intestinal permeability; disease; disease onset; rheumatology ... See more keywords
Delaying the first grapevine fungicide application reduces exposure on operators by half
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62954-4
Abstract: Downy mildew is a severe disease of grapevines treated by repeated fungicide applications during the growing season. The impact of these treatments on human health is currently under scrutiny. Fungicide application long before disease onset… read more here.
Keywords: delaying first; exposure; fungicide; disease onset ... See more keywords
Evaluation of a Model for Predicting Onset of Septoria nodorum blotch in Winter Wheat.
Sign Up to like & getrecommendations! Published in 2022 at "Plant disease"
DOI: 10.1094/pdis-06-22-1469-re
Abstract: Prediction models that aid growers in making decisions on fungicide application are important components in the integrated management programs for several foliar diseases of wheat. The risk of Septoria nodorum blotch (caused by Parastagonospora nodorum)… read more here.
Keywords: wheat; disease; model; septoria nodorum ... See more keywords
A Model for Predicting Onset of Stagonospora nodorum Blotch in Winter Wheat Based on Preplanting and Weather Factors.
Sign Up to like & getrecommendations! Published in 2017 at "Phytopathology"
DOI: 10.1094/phyto-03-16-0133-r
Abstract: Stagonospora nodorum blotch (SNB) caused by Parastagonospora nodorum is a serious disease of wheat worldwide. In the United States, the disease is prevalent on winter wheat in many eastern states, and its management relies mainly… read more here.
Keywords: wheat; disease; disease onset; model ... See more keywords
Multiple system atrophy with hippocampal pathology
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13067
Abstract: Ando et al. [1], in a recent study of 146 autopsyproven cases of multiple system atrophy (MSA) from various Japanese hospitals (82 males, 64 females, aged at disease onset 58.5 ± 9.3/33– 83/years) identified 12… read more here.
Keywords: hippocampal pathology; multiple system; pathology; cognitive impairment ... See more keywords
Age- and Occupation-Based Public Health Considerations Related to Osteoarthritis of the Knee Joint: A Cadaveric Study
Sign Up to like & getrecommendations! Published in 2019 at "CARTILAGE"
DOI: 10.1177/1947603517752432
Abstract: Objective Osteoarthritis (OA) literature makes minimal suggestion regarding age of disease onset or preventative strategies to reduce risk for onset in various populations. In 2005, the Centers for Disease Control and Prevention estimated that 33.6%… read more here.
Keywords: age; knee joint; cartilage; disease onset ... See more keywords