RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048880
Abstract: The RAG1 and RAG2 proteins initiate the process of V(D)J recombination and therefore play an essential role in adaptive immunity. While null mutations in the RAG genes cause severe combined immune deficiency with lack of… read more here.
Keywords: disease pathogenesis; deficiencies recent; rag deficiencies; pathogenesis novel ... See more keywords
Early‐Onset Osteoporosis: Rare Monogenic Forms Elucidate the Complexity of Disease Pathogenesis Beyond Type I Collagen
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4668
Abstract: Early‐onset osteoporosis (EOOP), characterized by low bone mineral density (BMD) and fractures, affects children, premenopausal women and men aged read more here.
Keywords: bone; monogenic forms; rare monogenic; disease pathogenesis ... See more keywords
miRNA in Parkinson's disease: From pathogenesis to theranostic approaches
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30932
Abstract: Parkinson's disease (PD) is an age associated neurological disorder which is specified by cardinal motor symptoms such as tremor, stiffness, bradykinesia, postural instability, and non‐motor symptoms. Dopaminergic neurons degradation in substantia nigra region and aggregation… read more here.
Keywords: pathogenesis theranostic; disease pathogenesis; mirna parkinson; parkinson disease ... See more keywords
Parkinson’s disease pathogenesis from the viewpoint of small fish models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1772-1
Abstract: Parkinson’s disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have… read more here.
Keywords: models parkinson; fish models; disease pathogenesis; small fish ... See more keywords
IL‐36&ggr; induces a transient HSV‐2 resistant environment that protects against genital disease and pathogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.07.034
Abstract: HighlightsHSV‐2 infection induces IL‐36&ggr; expression in human vaginal epithelial cells.HSV‐2 replication is limited by IL‐36&ggr; treatment in vitro and in vivo.IL‐36&ggr; induces immune mediators and PMN recruitment in the vaginal epithelium.Treatment with IL‐36&ggr; protects against… read more here.
Keywords: hsv; disease pathogenesis; treatment; infection ... See more keywords
Castleman Disease Pathogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2017.09.002
Abstract: Castleman disease (CD) describes a group of heterogeneous disorders with common lymph node histopathologic features, including atrophic or hyperplastic germinal centers, prominent follicular dendritic cells, hypervascularization, polyclonal lymphoproliferation, and/or polytypic plasmacytosis. The cause and pathogenesis… read more here.
Keywords: hematology; disease pathogenesis; pathogenesis; castleman disease ... See more keywords
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2022.03.002
Abstract: Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading… read more here.
Keywords: disease pathogenesis; respiratory viruses; influenza; diabetic patients ... See more keywords
Genetics of Alzheimer’s disease: From pathogenesis to clinical usage
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.06.074
Abstract: Alzheimer's disease (AD) is the most common type of dementia and has caused a major global health concern. Understanding the etiology of AD can be beneficial for the diagnosis and intervention of this disease. Genetics… read more here.
Keywords: disease pathogenesis; alzheimer disease; genetics; pathogenesis ... See more keywords
A New Chapter in Genetic Medicine: RNA Editing and its Role in Disease Pathogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.01.002
Abstract: The transfer of genomic information from DNA to mRNA to protein usually occurs with high fidelity, but can also be subverted by a programmed RNA sequence alteration termed 'RNA editing', involving deamination of adenosine to… read more here.
Keywords: medicine; disease pathogenesis; new chapter; rna editing ... See more keywords
Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2019.12.003
Abstract: Despite being an autosomal dominant disorder caused by a known coding mutation in the gene HTT, Huntington's disease (HD) patients with similar trinucleotide repeat mutations can have an age of onset that varies by decades.… read more here.
Keywords: alfy wdfy3; huntington disease; disease; disease pathogenesis ... See more keywords
Behçet disease: From pathogenesis to novel therapeutic options.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105593
Abstract: Behçet disease (BD) is a complex, multi-systemic inflammatory condition mainly hallmarked by oral and genital ulcers which can also affect the vessels, gastrointestinal tract, central nervous system and even the axial skeleton. Without a clear… read more here.
Keywords: pathogenesis novel; beh disease; therapeutic options; disease pathogenesis ... See more keywords