Updates on immunity and inflammation in Parkinson disease pathology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24185
Abstract: Studies in the last decade have suggested the association of both neuroinflammatory processes and immune responses in Parkinson disease (PD) pathology. PD pathology is related to depleted dopamine levels, α‐synuclein aggregation, and death of nigrostriatal… read more here.
Keywords: disease pathology; inflammation; disease; pathology ... See more keywords
Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project
Sign Up to like & getrecommendations! Published in 2019 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(18)30371-5
Abstract: BACKGROUND Some people with substantial Alzheimer's disease pathology at autopsy had shown few characteristic clinical symptoms or signs of the disease, whereas others with little Alzheimer's disease pathology have been diagnosed with Alzheimer's dementia. We… read more here.
Keywords: pathology; disease pathology; alzheimer disease; dementia ... See more keywords
Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51928-w
Abstract: Multiple animal models have been created to gain insight into Alzheimer’s disease (AD) pathology. Among the most commonly used models are transgenic mice overexpressing human amyloid precursor protein (APP) with mutations linked to familial AD,… read more here.
Keywords: disease pathology; alzheimer disease; app; pathology ... See more keywords
Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02211
Abstract: Background: Current ulcerative colitis (UC) treatments are focused on symptom management primarily via immune suppression. Despite the current arsenal of immunosuppressant treatments, the majority of patients with UC still experience disease progression. Importantly, aggressive long-term… read more here.
Keywords: disease pathology; pathology; colitis; ulcerative colitis ... See more keywords
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00598
Abstract: Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy function as well as the most common pathological conditions of the brain. Demographic factors, genetics, and lifestyles are… read more here.
Keywords: disease pathology; alzheimer disease; pathology; brain ... See more keywords
Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer’s Disease (AD) Pathology Than in Severe AD Pathology
Sign Up to like & getrecommendations! Published in 2018 at "Metabolites"
DOI: 10.3390/metabo8040069
Abstract: Brain is a lipid-rich tissue, and fatty acids (FAs) play a crucial role in brain function, including neuronal cell growth and development. This study used GC-MS to survey all detectable FAs in the human parietal… read more here.
Keywords: disease pathology; alzheimer disease; fatty acids; moderate alzheimer ... See more keywords