Effectiveness of Adding Everolimus to the First-line Treatment of Advanced Breast Cancer in Premenopausal Women Who Experienced Disease Progression While Receiving Selective Estrogen Receptor Modulators: A Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.3428
Abstract: Importance The effectiveness of the mammalian target of rapamycin (mTOR) inhibitor everolimus in premenopausal women with hormone receptor (HR)-positive/ERBB2-negative advanced breast cancer who experienced disease progression while receiving selective estrogen receptor modulators (SERMs) is unknown.… read more here.
Keywords: advanced breast; progression; breast cancer; disease progression ... See more keywords
Cortical hyperexcitability evolves with disease progression in ALS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51039
Abstract: Cortical hyperexcitability has been established as an early feature of amyotrophic lateral sclerosis (ALS). The evolution of cortical hyperexcitability with ALS progression remains to be fully elucidated. This study aims to investigate changes in cortical… read more here.
Keywords: hyperexcitability; cortical hyperexcitability; hyperexcitability evolves; disease progression ... See more keywords
Disease progression and brain atrophy in NMDAR encephalitis: Associated factor & clinical implication
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51604
Abstract: We investigated the longitudinal pattern, determining factors, and clinical implications of brain volume changes in N‐methyl d‐aspartate receptor‐antibody (NMDAR) encephalitis. read more here.
Keywords: progression brain; nmdar encephalitis; brain; brain atrophy ... See more keywords
Disease Progression in Charcot–Marie–Tooth Disease Related to MPZ Mutations: A Longitudinal Study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26518
Abstract: The paucity of longitudinal natural history studies in MPZ neuropathy remains a barrier to clinical trials. We have completed a longitudinal natural history study in patients with MPZ neuropathies across 13 sites of the Inherited… read more here.
Keywords: charcot marie; disease; progression charcot; disease progression ... See more keywords
Disease progression status during initial immune checkpoint inhibitor (ICI) affects the clinical outcome of ICI retreatment in advanced non-small cell lung cancer patients.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5939
Abstract: BACKGROUND It is still unclear whether patients with advanced non-small cell lung cancer (NSCLC), with disease progression after initial immune checkpoint inhibitor (ICI) therapy, would benefit from ICIs readministration. PATIENTS AND METHODS We retrospectively collected… read more here.
Keywords: ici; group; ici retreatment; disease progression ... See more keywords
Biobehavioral factors predict an exosome biomarker of ovarian carcinoma disease progression
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DOI: 10.1002/cncr.34496
Abstract: Biobehavioral factors such as social isolation and depression have been associated with disease progression in ovarian and other cancers. Here, the authors developed a noninvasive, exosomal RNA profile for predicting ovarian cancer disease progression and… read more here.
Keywords: predict exosome; factors predict; disease; disease progression ... See more keywords
Opportunities and Challenges of Disease Progression Modeling in Drug Development - An IQ Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2873
Abstract: Disease progression modeling (DPM) represents an important model-informed drug development framework. The scientific communities support the use of DPM to accelerate and increase efficiency in drug development. This article summarizes International Consortium for Innovation &… read more here.
Keywords: progression modeling; development; drug development; disease progression ... See more keywords
Characterization of neurological disease progression in a canine model of CLN5 neuronal ceroid lipofuscinosis.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental neurobiology"
DOI: 10.1002/dneu.22878
Abstract: Golden Retriever dogs with a frameshift variant in CLN5 (c.934_935delAG) suffer from a progressive neurodegenerative disorder analogous to the CLN5 form of neuronal ceroid lipofuscinosis (NCL). Five littermate puppies homozygous for the deletion allele were… read more here.
Keywords: neuronal ceroid; ceroid lipofuscinosis; disease progression; progression ... See more keywords
Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV‐1 CRF01_AE to downmodulate CD4
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24851
Abstract: Several HIV‐1 subtypes are co‐circulating among various high‐risk groups in China, and an increasing prevalence of CRF01_AE was observed among MSM (men who have sex with men) within recent years. Patients infected with CRF01_AE may… read more here.
Keywords: positions 168; hiv crf01; nef proteins; disease progression ... See more keywords
IL6 and FAS/FASL gene polymorphisms may be associated with disease progression in HIV‐1‐positive ethnically mixed patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25651
Abstract: The progression of AIDS depends on the complex host and virus interactions. The most important disease progression hallmarks are immune activation and apoptosis. In this study, we address the prevalence of polymorphisms related to proinflammatory… read more here.
Keywords: positive ethnically; ethnically mixed; disease progression; progression ... See more keywords
A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24596
Abstract: The rate of symptom accumulation distinguishes between slowly and rapidly progressing forms of multiple sclerosis (MS). Given that a patient's genetics can affect the rate of disease progression, identification of genetic variants associated with rapid… read more here.
Keywords: sclerosis; allele carriers; multiple sclerosis; disease progression ... See more keywords