Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26913
Abstract: Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by pancreatic β cells, the resistance of peripheral tissues to the action of the hormone, or both, and is characterized by chronic… read more here.
Keywords: safe option; chronic disease; disease setting; option chronic ... See more keywords
Design and analysis of drop-the-losers studies using binary endpoints in the rare disease setting
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2021.1918139
Abstract: ABSTRACT The drop-the-losers design combines a phase 2 trial of k treatments and a confirmatory phase 3 trial under a single adaptive protocol, thereby gaining efficiency over a traditional clinical development approach. Such designs may… read more here.
Keywords: design analysis; drop losers; disease setting; rare disease ... See more keywords
The Role of Haptoglobin Polymorphism in Cardiovascular Disease in the Setting of Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22010287
Abstract: Atherosclerotic cardiovascular disease (CVD) is the major cause of morbidity and mortality in individuals with diabetes mellitus (DM). Preclinical models have suggested that excessive oxidative stress and hyperglycemia are directly responsible for this pathological association.… read more here.
Keywords: disease setting; polymorphism cardiovascular; disease; role haptoglobin ... See more keywords