The biology and inhibition of glucose‐regulated protein 94/gp96
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21915
Abstract: The 94 kDa molecular chaperone, glucose‐regulated protein 94 (Grp94), has garnered interest during the last decade due to its direct association with endoplasmic reticulum (ER) stress and disease. Grp94 belongs to the Hsp90 family of molecular… read more here.
Keywords: inhibition; disease; glucose regulated; disease states ... See more keywords
Cyclin E in normal physiology and disease states.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.05.001
Abstract: E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by… read more here.
Keywords: cyclin normal; normal physiology; cyclin; physiology ... See more keywords
Social isolation and loneliness: Undervalued risk factors for disease states and mortality.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of clinical investigation"
DOI: 10.1111/eci.14032
Abstract: Social isolation and loneliness are two common but undervalued conditions associated with a poor quality of life, decreased overall health and mortality. In this review, we aim to discuss the health consequences of social isolation… read more here.
Keywords: disease states; isolation loneliness; isolation; social isolation ... See more keywords
Impact of gastrointestinal disease states on oral drug absorption – implications for formulation design – a PEARRL review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.12928
Abstract: Drug product performance in patients with gastrointestinal (GI) diseases can be altered compared to healthy subjects due to pathophysiological changes. In this review, relevant differences in patients with inflammatory bowel diseases, coeliac disease, irritable bowel… read more here.
Keywords: states oral; impact gastrointestinal; gastrointestinal disease; disease ... See more keywords
Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-215933
Abstract: Objective There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout. Methods… read more here.
Keywords: labels definitions; consensus; disease; gout ... See more keywords
Inclusion of Optimal Guidelines for Pharmacists in UpToDate
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Pharmacotherapy"
DOI: 10.1177/10600280211063950
Abstract: Clinical practice guidelines are an important aspect of evidence-based medicine but finding appropriate guidelines can be challenging. Freely available guidelinefocused databases exist, including ECRI Guidelines Trust, Guideline Central, Guidelines International Network (G-I-N), and the Turning… read more here.
Keywords: disease; guideline; optimal guidelines; disease states ... See more keywords
Gestational microbiome: metabolic perturbations and developmental programming.
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction"
DOI: 10.1530/rep-21-0241
Abstract: A growing body of research suggests that alterations to the human microbiome are associated with disease states, including obesity and diabetes. During pregnancy, these disease states are associated with maternal microbial dysbiosis. This review discusses… read more here.
Keywords: microbiome; disease states; microbiome metabolic; offspring microbiome ... See more keywords
The Human Extracellular Matrix Diseasome Reveals Genotype–Phenotype Associations with Clinical Implications for Age-Related Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11041212
Abstract: The extracellular matrix (ECM) is earning an increasingly relevant role in many disease states and aging. The analysis of these disease states is possible with the GWAS and PheWAS methodologies, and through our analysis, we… read more here.
Keywords: extracellular matrix; age; disease states; age related ... See more keywords