Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy263
Abstract: Abstract The calcium‐sensing receptor (CaSR) is a homodimeric G‐protein‐coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. The central importance of… read more here.
Keywords: loss gain; signalling bias; casr; calcium ... See more keywords