Disease Tolerance: Linking Sickness Behaviours to Metabolism Helps Mitigate Malaria
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.04.031
Abstract: Malaria-infected mice exhibit a range of sickness behaviours, and experience metabolic shifts and physiological pathologies that result in reduced energy expenditure. Treating sick mice with glucose increases disease tolerance by improving the physiological and behavioural… read more here.
Keywords: linking sickness; sickness behaviours; disease tolerance; tolerance linking ... See more keywords
Loss of disease tolerance during Citrobacter rodentium infection is associated with impaired epithelial differentiation and hyperactivation of T cell responses
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17386-y
Abstract: Citrobacter rodentium is an intestinal mouse pathogen widely used as a model to study the mucosal response to infection. Inbred mouse strains suffer one of two fates following infection: self-limiting colitis or fatal diarrheal disease.… read more here.
Keywords: rodentium infection; infection; rodentium; disease tolerance ... See more keywords
Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121244119
Abstract: Significance Disease resistance and tolerance are evolutionarily conserved yet distinct defense strategies that protect the host against microbial infection. Here, we report that taurolidine administered before the start of infection confers protection against polymicrobial sepsis… read more here.
Keywords: sepsis; disease tolerance; resistance; tolerance ... See more keywords
Mechanisms of damage prevention, signalling and repair impact disease tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2022.0837
Abstract: The insect gut is frequently exposed to pathogenic threats and must not only clear these potential infections, but also tolerate relatively high microbe loads. In contrast to the mechanisms that eliminate pathogens, we currently know… read more here.
Keywords: disease tolerance; damage prevention; tolerance; mechanisms damage ... See more keywords
The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00101-23
Abstract: The host immune response usually aims to inhibit virus replication in order to avoid cell damage and disease. In some cases, however, the infected host avoids the deleterious effects of infection despite high levels of… read more here.
Keywords: disease tolerance; disease; replication; host ... See more keywords
Disease tolerance: a protective mechanism of lung infections
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1037850
Abstract: Resistance and tolerance are two important strategies employed by the host immune response to defend against pathogens. Multidrug-resistant bacteria affect the resistance mechanisms involved in pathogen clearance. Disease tolerance, defined as the ability to reduce… read more here.
Keywords: disease tolerance; mechanism lung; tolerance;
Overexpression Levels of LbDREB6 Differentially Affect Growth, Drought, and Disease Tolerance in Poplar
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.528550
Abstract: The application of drought stress-regulating transcription factors (TFs) offers a credible way to improve drought tolerance in plants. However, many drought resistant TFs always showed unintended adverse effects on plant growth or other traits. Few… read more here.
Keywords: overexpression; tolerance; drought tolerance; growth ... See more keywords
Methodologies for Assessing Disease Tolerance in Pigs
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2018.00329
Abstract: Features of intensive farming can seriously threaten pig homeostasis, well-being and productivity. Disease tolerance of an organism is the adaptive ability in preserving homeostasis and at the same time limiting the detrimental impact that infection… read more here.
Keywords: tolerance; assessing disease; performance; disease tolerance ... See more keywords
The Impact of Helminth Coinfection on Innate and Adaptive Immune Resistance and Disease Tolerance during Toxoplasmosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200504
Abstract: More than 2 billion people worldwide are infected with helminths. Thus, it is possible for individuals to experience concomitant infection with helminth and intracellular microbes. Although the helminth-induced type 2 response can suppress type 1… read more here.
Keywords: disease tolerance; infection; coinfection; helminth coinfection ... See more keywords