Aging and age‐related diseases: from mechanisms to therapeutic strategies
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09910-5
Abstract: Aging is a physiological process mediated by numerous biological and genetic pathways, which are directly linked to lifespan and are a driving force for all age-related diseases. Human life expectancy has greatly increased in the… read more here.
Keywords: diseases mechanisms; mechanisms therapeutic; aging age; age related ... See more keywords
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Sign Up to like & getrecommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-025-02145-7
Abstract: In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for neurodegenerative diseases in… read more here.
Keywords: diseases mechanisms; antiageing strategy; mechanisms clinical; neurodegenerative diseases ... See more keywords
δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2020 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-019-0179-3
Abstract: Mammalian asparagine endopeptidase (AEP) is a cysteine protease that cleaves its protein substrates on the C-terminal side of asparagine residues. Converging lines of evidence indicate that AEP may be involved in the pathogenesis of several… read more here.
Keywords: diseases mechanisms; secretase neurodegenerative; regulators therapeutic; neurodegenerative diseases ... See more keywords
Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications
Sign Up to like & getrecommendations! Published in 2025 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s505355
Abstract: Abstract Exosomes, small extracellular vesicles secreted by various cells, play crucial roles in the pathogenesis and treatment of oral diseases. Recent studies have highlighted their involvement in orthodontics, periodontitis, oral squamous cell carcinoma (OSCC), and… read more here.
Keywords: oral diseases; diseases mechanisms; exosomes oral; therapeutic applications ... See more keywords
Flavonoids in Autoimmune Diseases: Mechanisms, Clinical Evidence, and Future Directions.
Sign Up to like & getrecommendations! Published in 2025 at "Current pharmaceutical biotechnology"
DOI: 10.2174/0113892010399864251028081855
Abstract: Autoimmune diseases remain one of the top leading causes of morbidity and mortality globally. While several first-line therapies like corticosteroids, immunosuppressants, and DMARDs are proven effective, their prolonged use often leads to drug-induced complications. Researchers… read more here.
Keywords: diseases mechanisms; mechanisms clinical; clinical evidence; autoimmune diseases ... See more keywords
The role of deubiquitinases in cardiovascular diseases: mechanisms and therapeutic implications
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2025.1582049
Abstract: Cardiovascular diseases (CVDs) have become the leading cause of death globally, surpassing infectious diseases and other chronic illnesses. The incidence and mortality rates of CVDs are rising worldwide, posing a key challenge in public health.… read more here.
Keywords: diseases mechanisms; role deubiquitinases; role; mechanisms therapeutic ... See more keywords
Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032706
Abstract: Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates of mortality and decreased rates of neurological and metabolic diseases, including Parkinson’s disease and type… read more here.
Keywords: coffee; coffee consumption; health benefits; diseases mechanisms ... See more keywords
Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043385
Abstract: Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use… read more here.
Keywords: mechanisms behind; behind story; diseases mechanisms; molecules cardiometabolic ... See more keywords
The cGAS-STING Pathway in Pulmonary Diseases: Mechanisms and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms262110423
Abstract: The cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway, a central innate immune sensor of cytosolic DNA, plays a dual role in immunoregulation within pulmonary diseases. Recent studies demonstrate its critical role in sensing microbial… read more here.
Keywords: diseases mechanisms; pulmonary diseases; pathway pulmonary; sting pathway ... See more keywords