Glial activation in prion diseases is selectively triggered by neuronal PrPSc.
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DOI: 10.1111/bpa.13056
Abstract: Although prion infections cause cognitive impairment and neuronal death, transcriptional and translational profiling shows progressive derangement within glia but surprisingly little changes within neurons. Here we expressed PrPC selectively in neurons and astrocytes of mice.… read more here.
Keywords: prion diseases; diseases selectively; prpsc; prion ... See more keywords