Dynamic interplay of microRNA in diseases and therapeutic
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14256
Abstract: MicroRNAs are the major class of small nonâcoding RNAs, evolutionary conserved postâtranscriptional regulators of gene expression. Since their discovery in 1993, they have been implicated as master regulators in numerous cellular processes. MicroRNA (miRNA)s regulate… read more here.
Keywords: interplay microrna; microrna diseases; dynamic interplay; diseases therapeutic ... See more keywords
Patients with rare diseases: from therapeutic orphans to pioneers of personalized treatments
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DOI: 10.15252/emmm.201708365
Abstract: Common diseases, such as cancer, diabetes mellitus, or Alzheimer's disease, affect a large segment of the population, which justifies the enormous financial allocations for translational and clinical research. In contrast, the ~5,000 known rare disorders… read more here.
Keywords: medicine; orphans pioneers; rare diseases; therapeutic orphans ... See more keywords
Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
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DOI: 10.2147/jir.s352563
Abstract: Abstract Pyroptosis is an inflammatory type of regulated cell death that is dependent on inflammasome activation and downstream proteases such as caspase-1 or caspase 4/5/11. The main executors are gasdermins, which have an inherent pore-forming… read more here.
Keywords: pyroptosis; role pyroptosis; diseases therapeutic; respiratory diseases ... See more keywords
Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies
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DOI: 10.3390/biomedicines11051500
Abstract: Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for various physiological activities of the cell. Cardiomyocytes have a high density of mitochondria and mitochondrial damage is present in a variety… read more here.
Keywords: therapeutic strategies; cardiac diseases; dysfunction cardiac; mitochondrial dysfunction ... See more keywords
A-FABP in Metabolic Diseases and the Therapeutic Implications: An Update
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DOI: 10.3390/ijms22179386
Abstract: Adipocyte fatty acid-binding protein (A-FABP), which is also known as ap2 or FABP4, is a fatty acid chaperone that has been further defined as a fat-derived hormone. It regulates lipid homeostasis and is a key… read more here.
Keywords: fabp metabolic; metabolic diseases; therapeutic implications; implications update ... See more keywords