Engineering folate-targeting diselenide-containing triblock copolymer as a redox-responsive shell-sheddable micelle for antitumor therapy in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.031
Abstract: The oxidation-reduction (redox)-responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2]. This has helped in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as a… read more here.
Keywords: redox responsive; micelle; redox; diselenide containing ... See more keywords
Selenolactone as a Building Block toward Dynamic Diselenide-Containing Polymer Architectures with Controllable Topology
Sign Up to like & getrecommendations! Published in 2017 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.6b00944
Abstract: A versatile protocol for the synthesis of a variety of multiresponsive diselenide-containing polymeric architectures was investigated. It consists of a one-pot, two-step process with the generation of a selenol by in situ nucleophilic ring opening… read more here.
Keywords: diselenide containing; topology; polymer; selenolactone building ... See more keywords