Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.
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DOI: 10.3324/haematol.2021.278469
Abstract: Shedding of A Disintegrin And Metalloproteinases (ADAM10) substrates, like TNFα or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent… read more here.
Keywords: lymphoma; hodgkin lymphoma; disintegrin metalloproteinases; adam10 inhibitors ... See more keywords