Bu‐Shen‐Huo‐Xue‐Fang modulates nucleus pulposus cell proliferation and extracellular matrix remodeling in intervertebral disk degeneration through miR‐483 regulation of Wnt pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26760
Abstract: Intervertebral disk degeneration (IDD) has been widely considered as one of the main causes for low back pain, which can cause a severe impact to human health and huge economic burden to worldwide society. IDD… read more here.
Keywords: disk degeneration; cell proliferation; intervertebral disk; wnt ... See more keywords
Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.1012
Abstract: Low back pain (LBP) is a common disorder in orthopedic outpatients, affecting people of all ages, and some patients may develop chronic LBP. As a complex organelle, mitochondria are not only energy workstations but also… read more here.
Keywords: mitochondrial dysfunction; disk degeneration; dysfunction intervertebral; intervertebral disk ... See more keywords
External Validation of SpineNet, an Open-Source Deep Learning Model for Grading Lumbar Disk Degeneration MRI Features, Using the Northern Finland Birth Cohort 1966
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DOI: 10.1097/brs.0000000000004572
Abstract: Study Design. This is a retrospective observational study to externally validate a deep learning image classification model. Objective. Deep learning models such as SpineNet offer the possibility of automating the process of disk degeneration (DD)… read more here.
Keywords: reliability; disk degeneration; mri; deep learning ... See more keywords
Long Fusion Arthrodesis Stopping at L5 for Adult Scoliosis: Fate of L5–S1 Disk and Risk Factors for Subsequent Disk Degeneration
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DOI: 10.1097/bsd.0000000000000624
Abstract: Study Design: This is retrospective study. Objective: Our purpose is to examine the state of the L5–S1 disk after long fusion arthrodesis stopping at L5 in adult scoliosis, and to identify the risk factors for… read more here.
Keywords: disk degeneration; disk; adult scoliosis; arthrodesis ... See more keywords
Modic Changes in the Lumbar Spine are Common Aging-related Degenerative Findings that Parallel With Disk Degeneration
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DOI: 10.1097/bsd.0000000000000662
Abstract: Study Design: This is a cross-sectional study. Objective: To determine the prevalence and distribution patterns of Modic changes (MCs) in the lumbar spine and their associations with disk degeneration in mainland Chinese using a sample… read more here.
Keywords: disk degeneration; mcs; lumbar spine; degeneration ... See more keywords
Twenty-year Longitudinal Follow-up MRI Study of Asymptomatic Volunteers: The Impact of Cervical Alignment on Disk Degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Spine Surgery"
DOI: 10.1097/bsd.0000000000000706
Abstract: Study Design: A 20-year longitudinal study. Objective: To evaluate the long-term effect of sagittal alignment of the cervical spine on intervertebral disk degeneration in healthy asymptomatic subjects. Summary of Background Data: This study continues a… read more here.
Keywords: disk degeneration; disk; alignment; year ... See more keywords
MiR-206 improves intervertebral disk degeneration by targeting GJA1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-022-03044-1
Abstract: Background A large amount of evidence suggested that miRNA was involved in the progression of intervertebral disk degeneration (IDD). The purpose of our study was to explore the function and potential mechanism of miR-206/GJA1 axis… read more here.
Keywords: idd; gja1; disk degeneration; targeting gja1 ... See more keywords
How Should We Grade Cervical Disk Degeneration? A Comparison of Two Popular Classification Systems
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DOI: 10.22603/ssrr.2021-0048
Abstract: Introduction Despite being originally developed for the evaluation of lumbar disk degeneration, the Pfirrmann classification has emerged as the most popular classification system for cervical disk degeneration. However, with the Suzuki classification, a new classification… read more here.
Keywords: disk degeneration; classification; disk; suzuki classification ... See more keywords
Cytokine Imbalance as a Biomarker of Intervertebral Disk Degeneration
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032360
Abstract: The intervertebral disk degeneration (IDD) and its associated conditions are an important problem in modern medicine. The onset of IDD may be in childhood and adolescence in patients with a genetic predisposition. IDD progresses with… read more here.
Keywords: disk degeneration; cytokine imbalance; intervertebral disk;