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   Articles with "disoproxil fumarate" as a keyword



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Lack of a Clinically Meaningful Drug Interaction Between the HIV-1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate.

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recommendations! Published in 2021 at "Clinical pharmacology in drug development"

DOI: 10.1002/cpdd.1026

Abstract: Islatravir, an investigational nucleoside reverse transcriptase translocation inhibitor, is in clinical development for the treatment and prevention of HIV-1 infection. Because islatravir may be coadministered with other antiretroviral agents, assessment of potential drug-drug interactions are… read more here.

Keywords: islatravir dolutegravir; antiretroviral agents; disoproxil fumarate; drug ... See more keywords
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Tenofovir alafenamide is associated with improved alanine aminotransferase and renal safety compared to tenofovir disoproxil fumarate

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.27863

Abstract: Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir for the treatment of chronic hepatitis B (CHB) infection. We aimed to evaluate the impact of switching to TAF on alanine aminotransferase (ALT) normalization and renal… read more here.

Keywords: safety; alanine aminotransferase; renal safety; tenofovir disoproxil ... See more keywords
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Real‐life impact of tenofovir disoproxil fumarate and entecavir therapy on lipid profile, glucose, and uric acid in chronic hepatitis B patients

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.27977

Abstract: The impact of long‐term nucleos(t)ide analogs treatment on host metabolism is a concern. Hence, we conducted this study to compare the effect of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) on metabolic parameters among chronic… read more here.

Keywords: real life; chronic hepatitis; tenofovir disoproxil; treated patients ... See more keywords
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Determination of enantiomeric impurity of tenofovir disoproxil fumarate on a cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase and the characterization of its related substances.

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recommendations! Published in 2021 at "Journal of separation science"

DOI: 10.1002/jssc.202100011

Abstract: A simple and reliable HPLC method was developed to determine the enantiomeric impurity of tenofovir disoproxil fumarate, an orally bioavailable prodrug of tenofovir, commonly used for the treatment of human immunodeficiency virus and hepatitis B.… read more here.

Keywords: tenofovir disoproxil; enantiomeric impurity; disoproxil fumarate; tenofovir ... See more keywords
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Tenofovir disoproxil fumarate associated nephrotoxicity: a retrospective cohort study at two referral hospitals in Namibia

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recommendations! Published in 2020 at "Pharmacoepidemiology and Drug Safety"

DOI: 10.1002/pds.5125

Abstract: The incidence and risk factors of tenofovir disoproxil fumarate (TDF)‐related renal impairment (RI) in Namibia are unknown where TDF‐containing ART regimens are used as the first line for HIV. read more here.

Keywords: associated nephrotoxicity; disoproxil fumarate; tenofovir disoproxil; nephrotoxicity retrospective ... See more keywords
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Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections in vitro.

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recommendations! Published in 2017 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.08.061

Abstract: Sexually transmitted infections affect hundreds of millions of people worldwide. Both human immunodeficiency virus (HIV-1 and -2) and herpes simplex virus-2 (HSV-2) remain incurable, urging the development of new prevention strategies. While current prophylactic technologies… read more here.

Keywords: hsv; hiv hsv; disoproxil fumarate; hiv ... See more keywords
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A Simple Stability Indicating Rp-Hplc-Dad Method For Concurrent Analysis Of Tenofovir Disoproxil Fumarate, Doravirine And Lamivudine In Pure Blend And Their Combined Film Coated Tablets.

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recommendations! Published in 2021 at "Annales pharmaceutiques francaises"

DOI: 10.1016/j.pharma.2021.04.006

Abstract: OBJECTIVES The main aim of the study was to develop an economical, insightful,accurate and simple RP-HPLC-DAD method with high precision and good sensitivity for concurrent determination of Tenofovir disoproxil fumarate, Doravirine and Lamivudine in blended… read more here.

Keywords: tenofovir disoproxil; disoproxil fumarate; doravirine lamivudine; method ... See more keywords
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Oral pharmacokinetic interaction of ester rich fruit juices and pharmaceutical excipients with tenofovir disoproxil fumarate in male Wistar rats

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recommendations! Published in 2017 at "Xenobiotica"

DOI: 10.1080/00498254.2016.1269375

Abstract: Abstract 1. The aim of this study was to evaluate the role of intestinal esterases on the absorption process of tenofovir disoproxil fumarate (TDF). 2. The esterase inhibition capacity of fruit juices (FJs) rich in ester linkages… read more here.

Keywords: disoproxil fumarate; tenofovir disoproxil; fruit juices; pharmaceutical excipients ... See more keywords
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Switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide Significantly Worsens the Lipid Profile in a Real-World Setting.

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recommendations! Published in 2019 at "AIDS patient care and STDs"

DOI: 10.1089/apc.2019.0236

Abstract: Tenofovir disoproxil fumarate (TDF) has increasingly been replaced by tenofovir alafenamide (TAF) because of reduced kidney and bone toxicity with TAF. This switch has, however, caused worsening of lipid concentrations in clinical trials, but data… read more here.

Keywords: real world; disoproxil fumarate; cholesterol; tenofovir disoproxil ... See more keywords
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Safety of Tenofovir Disoproxil Fumarate (TDF) for Pregnant Women facing the COVID-19 Pandemic

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recommendations! Published in 2021 at "American Journal of Epidemiology"

DOI: 10.1093/aje/kwab109

Abstract: Abstract We assessed the teratogenicity of tenofovir, a human immunodeficiency virus (HIV) drug similar to remdesivir currently being evaluated for the treatment of coronavirus disease 2019 (COVID-19). Using US Medicaid Analytic Extract (MAX) claims data… read more here.

Keywords: disoproxil fumarate; safety tenofovir; tenofovir disoproxil; fumarate tdf ... See more keywords
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Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate: A Randomized, Placebo-Controlled Trial

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recommendations! Published in 2018 at "Clinical Infectious Diseases"

DOI: 10.1093/cid/cix753

Abstract: Background Tenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized that vitamin D3 (VITD3) would increase BMD in youth receiving TDF. Methods This was a randomized, double-blind, placebo-controlled trial of directly observed VITD3… read more here.

Keywords: bone mineral; disoproxil fumarate; vitd3; tenofovir disoproxil ... See more keywords