Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100941
Abstract: Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds to sterols… read more here.
Keywords: phase; phase separation; cholesterol disordered; disordered domains ... See more keywords
Rational Control of the Activity of a Cu2+-Dependent DNAzyme by Re-engineering Purely Entropic Intrinsically Disordered Domains.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c09472
Abstract: The function and activity of many proteins is finely controlled by the modulation of the entropic contribution of intrinsically disordered domains that are not directly involved in any recognition event. Inspired by this mechanism, we… read more here.
Keywords: disordered domains; cu2 dependent; dependent dnazyme; activity ... See more keywords
Intrinsically Disordered Domains, Amyloids and Protein Liquid Phases: Evolving Concepts and Open Questions.
Sign Up to like & getrecommendations! Published in 2017 at "Protein and peptide letters"
DOI: 10.2174/0929866524666170206122106
Abstract: Enzymes and structural proteins dominated thinking about protein structure and function for most of the twentieth century. In recent decades, however, we have begun to appreciate the significant physiological and pathological roles of nonglobular proteins.… read more here.
Keywords: disordered domains; domains amyloids; liquid phases; protein liquid ... See more keywords
Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2018.00039
Abstract: Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we… read more here.
Keywords: disordered domains; fuzzy interactions; interactions involving; intramolecular fuzzy ... See more keywords