Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation.
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DOI: 10.1021/acs.biochem.7b00776
Abstract: Protein misfolding due to mutation(s) and/or generation of unstable intermediate state(s) can be the cause of aberrant aggregations, leading to cellular degeneration. While molecular signatures like amyloidogenic regions cause aggregation, other features in proteins, like… read more here.
Keywords: protein; aggregation; disordered nanostructure; huntingtin interacting ... See more keywords